Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein
Objective: To analyse clinical and molecular features in patients with surgically resected patients with lung cancer harbouring anaplastic lymphoma kinase fusion. Methods: The retrospective study was conducted at Zhejiang Cancer Hospital, Hangzhou, China, and comprised data from November 2013 to...
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2020-11-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/2101 |
| _version_ | 1797820621554450432 |
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| author | Zhiming Jiang Chenghui Li Hongyang Lu |
| author_facet | Zhiming Jiang Chenghui Li Hongyang Lu |
| author_sort | Zhiming Jiang |
| collection | DOAJ |
| description |
Objective: To analyse clinical and molecular features in patients with surgically resected patients with lung cancer harbouring anaplastic lymphoma kinase fusion.
Methods: The retrospective study was conducted at Zhejiang Cancer Hospital, Hangzhou, China, and comprised data from November 2013 to August 2015 of lung cancer patients. Anaplastic lymphoma kinase, epidermal growth factor receptor, kirsten rat sarcoma viral oncogene, v-raf murine sarcoma viral oncogene homolog, REarranged during Transfection proto-oncogene, c-ros oncogene 1 receptor kinase, V-Erb-B2 avian erythroblastic leukaemia viral oncogene homolog 2 and mesenchymal epithelial transition factor were noted using next generation sequencing. Clinicopathological parameters were also investigated. All patients were followed up till August 10, 2017. Data was analysed using SPSS 22.
Results: Of the 19 patients, 15(79%) were non-smokers. Anaplastic lymphoma kinase rearrangements occurred in the acinar predominant in 6(31.6%), Continuous...
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| first_indexed | 2024-03-13T09:41:58Z |
| format | Article |
| id | doaj.art-e46824d53e904e1691c46cf741a1c7f0 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:41:58Z |
| publishDate | 2020-11-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-e46824d53e904e1691c46cf741a1c7f02023-05-25T04:24:54ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822020-11-0171210.47391/JPMA.1295Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion proteinZhiming Jiang0Chenghui Li1Hongyang Lu2Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, ChinaZhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Hangzhou, China Objective: To analyse clinical and molecular features in patients with surgically resected patients with lung cancer harbouring anaplastic lymphoma kinase fusion. Methods: The retrospective study was conducted at Zhejiang Cancer Hospital, Hangzhou, China, and comprised data from November 2013 to August 2015 of lung cancer patients. Anaplastic lymphoma kinase, epidermal growth factor receptor, kirsten rat sarcoma viral oncogene, v-raf murine sarcoma viral oncogene homolog, REarranged during Transfection proto-oncogene, c-ros oncogene 1 receptor kinase, V-Erb-B2 avian erythroblastic leukaemia viral oncogene homolog 2 and mesenchymal epithelial transition factor were noted using next generation sequencing. Clinicopathological parameters were also investigated. All patients were followed up till August 10, 2017. Data was analysed using SPSS 22. Results: Of the 19 patients, 15(79%) were non-smokers. Anaplastic lymphoma kinase rearrangements occurred in the acinar predominant in 6(31.6%), Continuous... https://www.ojs.jpma.org.pk/index.php/public_html/article/view/2101 |
| spellingShingle | Zhiming Jiang Chenghui Li Hongyang Lu Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein Journal of the Pakistan Medical Association |
| title | Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| title_full | Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| title_fullStr | Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| title_full_unstemmed | Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| title_short | Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| title_sort | next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/2101 |
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