Tropheryma whipplei-induced plastic bronchitis in children: a case report
This article reports a case of a 7-year-old child with severe pneumonia whose chest CT showed pulmonary consolidation, and bronchoscopy revealed plastic bronchitis. The metagenomic Next-Generation Sequencing (NGS) of the pulmonary lavage fluid suggested the infection of Tropheryma whipplei (T whippl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1185519/full |
| _version_ | 1797809811577896960 |
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| author | Xuefeng Jin Caiyun Zhang Chao Chen Xiaoning Wang Jing Dong Yuanyuan He Peng Zhang |
| author_facet | Xuefeng Jin Caiyun Zhang Chao Chen Xiaoning Wang Jing Dong Yuanyuan He Peng Zhang |
| author_sort | Xuefeng Jin |
| collection | DOAJ |
| description | This article reports a case of a 7-year-old child with severe pneumonia whose chest CT showed pulmonary consolidation, and bronchoscopy revealed plastic bronchitis. The metagenomic Next-Generation Sequencing (NGS) of the pulmonary lavage fluid suggested the infection of Tropheryma whipplei (T whipplei). The patient was treated with bronchial lavage to remove sputum plugs, intravenous azithromycin, and piperacillin-tazobactam and was discharged after eight days of hospitalization without any recurrence during follow-up. This article aims to raise clinical awareness of T whipplei infection and suggests that NGS for rare pathogens should be performed early for unexplained plastic bronchitis. |
| first_indexed | 2024-03-13T06:58:25Z |
| format | Article |
| id | doaj.art-e468465dbb664c0a950a04a701c88812 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-13T06:58:25Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-e468465dbb664c0a950a04a701c888122023-06-07T05:04:24ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-06-011110.3389/fped.2023.11855191185519Tropheryma whipplei-induced plastic bronchitis in children: a case reportXuefeng Jin0Caiyun Zhang1Chao Chen2Xiaoning Wang3Jing Dong4Yuanyuan He5Peng Zhang6Department of Gastroenterology, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaPediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, ChinaThis article reports a case of a 7-year-old child with severe pneumonia whose chest CT showed pulmonary consolidation, and bronchoscopy revealed plastic bronchitis. The metagenomic Next-Generation Sequencing (NGS) of the pulmonary lavage fluid suggested the infection of Tropheryma whipplei (T whipplei). The patient was treated with bronchial lavage to remove sputum plugs, intravenous azithromycin, and piperacillin-tazobactam and was discharged after eight days of hospitalization without any recurrence during follow-up. This article aims to raise clinical awareness of T whipplei infection and suggests that NGS for rare pathogens should be performed early for unexplained plastic bronchitis.https://www.frontiersin.org/articles/10.3389/fped.2023.1185519/fulltropheryma whippleiplastic bronchitischildrenpiperacillin-tazobactamneat-generation sequencing |
| spellingShingle | Xuefeng Jin Caiyun Zhang Chao Chen Xiaoning Wang Jing Dong Yuanyuan He Peng Zhang Tropheryma whipplei-induced plastic bronchitis in children: a case report Frontiers in Pediatrics tropheryma whipplei plastic bronchitis children piperacillin-tazobactam neat-generation sequencing |
| title | Tropheryma whipplei-induced plastic bronchitis in children: a case report |
| title_full | Tropheryma whipplei-induced plastic bronchitis in children: a case report |
| title_fullStr | Tropheryma whipplei-induced plastic bronchitis in children: a case report |
| title_full_unstemmed | Tropheryma whipplei-induced plastic bronchitis in children: a case report |
| title_short | Tropheryma whipplei-induced plastic bronchitis in children: a case report |
| title_sort | tropheryma whipplei induced plastic bronchitis in children a case report |
| topic | tropheryma whipplei plastic bronchitis children piperacillin-tazobactam neat-generation sequencing |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1185519/full |
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