Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
<h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236428/?tool=EBI |
| _version_ | 1818721703119814656 |
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| author | Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens |
| author_facet | Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens |
| author_sort | Pierre-Régis Burgel |
| collection | DOAJ |
| description | <h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD subjects (n = 527) were classified using hierarchical cluster analysis of clinical, functional and imaging data. The relevance of this classification was validated using prospective follow-up of mortality.<h4>Results</h4>The most relevant patient classification was that based on three clusters (phenotypes). Phenotype 1 included subjects at very low risk of mortality, who had mild respiratory disease and low rates of comorbidities. Phenotype 2 and 3 were at high risk of mortality. Phenotype 2 included younger subjects with severe airflow limitation, emphysema and hyperinflation, low body mass index, and low rates of cardiovascular comorbidities. Phenotype 3 included older subjects with less severe respiratory disease, but higher rates of obesity and cardiovascular comorbidities. Mortality was associated with the severity of airflow limitation in Phenotype 2 but not in Phenotype 3 subjects, and subjects in Phenotype 2 died at younger age.<h4>Conclusions</h4>We identified three COPD phenotypes, including two phenotypes with high risk of mortality. Subjects within these phenotypes may require different therapeutic interventions to improve their outcome. |
| first_indexed | 2024-12-17T20:42:56Z |
| format | Article |
| id | doaj.art-e46856e48e8240e289f8c602d6f17522 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T20:42:56Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e46856e48e8240e289f8c602d6f175222022-12-21T21:33:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5104810.1371/journal.pone.0051048Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.Pierre-Régis BurgelJean-Louis PaillasseurBernard PeeneDaniel DusserNicolas RocheJohan CoolenThierry TroostersMarc DecramerWim Janssens<h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD subjects (n = 527) were classified using hierarchical cluster analysis of clinical, functional and imaging data. The relevance of this classification was validated using prospective follow-up of mortality.<h4>Results</h4>The most relevant patient classification was that based on three clusters (phenotypes). Phenotype 1 included subjects at very low risk of mortality, who had mild respiratory disease and low rates of comorbidities. Phenotype 2 and 3 were at high risk of mortality. Phenotype 2 included younger subjects with severe airflow limitation, emphysema and hyperinflation, low body mass index, and low rates of cardiovascular comorbidities. Phenotype 3 included older subjects with less severe respiratory disease, but higher rates of obesity and cardiovascular comorbidities. Mortality was associated with the severity of airflow limitation in Phenotype 2 but not in Phenotype 3 subjects, and subjects in Phenotype 2 died at younger age.<h4>Conclusions</h4>We identified three COPD phenotypes, including two phenotypes with high risk of mortality. Subjects within these phenotypes may require different therapeutic interventions to improve their outcome.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236428/?tool=EBI |
| spellingShingle | Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. PLoS ONE |
| title | Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. |
| title_full | Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. |
| title_fullStr | Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. |
| title_full_unstemmed | Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. |
| title_short | Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. |
| title_sort | two distinct chronic obstructive pulmonary disease copd phenotypes are associated with high risk of mortality |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236428/?tool=EBI |
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