Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis
Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Future Science Ltd
2023-12-01
|
| Series: | Future Science OA |
| Subjects: | |
| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2023-0109 |
| _version_ | 1797393902476460032 |
|---|---|
| author | Mona Boudabbous Baha Barkia Wiem Feki Héla Gdoura Lassad Chtourou Manel Moalla Leila Mnif Ali Amouri Zeinab Mnif Nabil Tahri |
| author_facet | Mona Boudabbous Baha Barkia Wiem Feki Héla Gdoura Lassad Chtourou Manel Moalla Leila Mnif Ali Amouri Zeinab Mnif Nabil Tahri |
| author_sort | Mona Boudabbous |
| collection | DOAJ |
| description | Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage. |
| first_indexed | 2024-03-09T00:10:41Z |
| format | Article |
| id | doaj.art-e4686d398d124033ab14293d3c43ea86 |
| institution | Directory Open Access Journal |
| issn | 2056-5623 |
| language | English |
| last_indexed | 2024-03-09T00:10:41Z |
| publishDate | 2023-12-01 |
| publisher | Future Science Ltd |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj.art-e4686d398d124033ab14293d3c43ea862023-12-12T10:10:20ZengFuture Science LtdFuture Science OA2056-56232023-12-0110.2144/fsoa-2023-0109Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosisMona Boudabbous0Baha Barkia1Wiem Feki2Héla Gdoura3Lassad Chtourou4Manel Moalla5Leila Mnif6Ali Amouri7Zeinab Mnif8Nabil Tahri91Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia2Radiology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia2Radiology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia1Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, TunisiaAim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.https://www.future-science.com/doi/10.2144/fsoa-2023-0109combination therapyinflammatory bowel diseasesquamous cell carcinomathiopurines |
| spellingShingle | Mona Boudabbous Baha Barkia Wiem Feki Héla Gdoura Lassad Chtourou Manel Moalla Leila Mnif Ali Amouri Zeinab Mnif Nabil Tahri Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis Future Science OA combination therapy inflammatory bowel disease squamous cell carcinoma thiopurines |
| title | Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis |
| title_full | Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis |
| title_fullStr | Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis |
| title_full_unstemmed | Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis |
| title_short | Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis |
| title_sort | squamous cell carcinoma and crohn s disease a sometimes challenging diagnosis |
| topic | combination therapy inflammatory bowel disease squamous cell carcinoma thiopurines |
| url | https://www.future-science.com/doi/10.2144/fsoa-2023-0109 |
| work_keys_str_mv | AT monaboudabbous squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT bahabarkia squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT wiemfeki squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT helagdoura squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT lassadchtourou squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT manelmoalla squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT leilamnif squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT aliamouri squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT zeinabmnif squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis AT nabiltahri squamouscellcarcinomaandcrohnsdiseaseasometimeschallengingdiagnosis |