Modeling the pathway of breast cancer in the Middle East
This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium i.e. Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expans...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-01-01
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| Series: | Applied Mathematics and Nonlinear Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amns.2021.2.00050 |
| _version_ | 1797688856233902080 |
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| author | Amer Asmaa Nagah Ahmed Osman Mojeeb AL-Rahman El-Nor Majid Abdul |
| author_facet | Amer Asmaa Nagah Ahmed Osman Mojeeb AL-Rahman El-Nor Majid Abdul |
| author_sort | Amer Asmaa |
| collection | DOAJ |
| description | This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium i.e. Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expansion of intermediate cells. We fit the data-set related to the incidence of female breast cancer in the four member countries. Our simulation results show that the maximum number of driver mutations of breast epithelium stem cells of Egyptian women is 13, whereas there are 14 driver mutations in the genome of stem cells of female patients in Jordan, Cyprus and Israel (Arabs and Jews). In addition, the 3, 10, 5, 5 and 4 stage models are the optimal ones for the tumorigenesis of females in Egypt, Jordan, Cyprus, Israel (Arabs) and Israel (Jews), respectively. The genomic instability is caused by first three driver mutations. |
| first_indexed | 2024-03-12T01:36:41Z |
| format | Article |
| id | doaj.art-e468e55ebb284ce18d55721404a74828 |
| institution | Directory Open Access Journal |
| issn | 2444-8656 |
| language | English |
| last_indexed | 2024-03-12T01:36:41Z |
| publishDate | 2023-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Applied Mathematics and Nonlinear Sciences |
| spelling | doaj.art-e468e55ebb284ce18d55721404a748282023-09-11T07:01:07ZengSciendoApplied Mathematics and Nonlinear Sciences2444-86562023-01-018114716610.2478/amns.2021.2.00050Modeling the pathway of breast cancer in the Middle EastAmer Asmaa0Nagah Ahmed1Osman Mojeeb AL-Rahman El-Nor2Majid Abdul31School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, P. R. China1School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, P. R. China1School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, P. R. China1School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, P. R. ChinaThis paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium i.e. Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expansion of intermediate cells. We fit the data-set related to the incidence of female breast cancer in the four member countries. Our simulation results show that the maximum number of driver mutations of breast epithelium stem cells of Egyptian women is 13, whereas there are 14 driver mutations in the genome of stem cells of female patients in Jordan, Cyprus and Israel (Arabs and Jews). In addition, the 3, 10, 5, 5 and 4 stage models are the optimal ones for the tumorigenesis of females in Egypt, Jordan, Cyprus, Israel (Arabs) and Israel (Jews), respectively. The genomic instability is caused by first three driver mutations.https://doi.org/10.2478/amns.2021.2.00050breast cancermulti-stage modelincidence ratechi square test |
| spellingShingle | Amer Asmaa Nagah Ahmed Osman Mojeeb AL-Rahman El-Nor Majid Abdul Modeling the pathway of breast cancer in the Middle East Applied Mathematics and Nonlinear Sciences breast cancer multi-stage model incidence rate chi square test |
| title | Modeling the pathway of breast cancer in the Middle East |
| title_full | Modeling the pathway of breast cancer in the Middle East |
| title_fullStr | Modeling the pathway of breast cancer in the Middle East |
| title_full_unstemmed | Modeling the pathway of breast cancer in the Middle East |
| title_short | Modeling the pathway of breast cancer in the Middle East |
| title_sort | modeling the pathway of breast cancer in the middle east |
| topic | breast cancer multi-stage model incidence rate chi square test |
| url | https://doi.org/10.2478/amns.2021.2.00050 |
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