Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination
Myelination is critical for fast saltatory conduction of action potentials. Recent studies have revealed that myelin is not a static structure as previously considered but continues to be made and remodeled throughout adulthood in tune with the network requirement. Synthesis of new myelin requires t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.1041853/full |
| _version_ | 1817971149657604096 |
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| author | Christopher D. Fekete Akiko Nishiyama |
| author_facet | Christopher D. Fekete Akiko Nishiyama |
| author_sort | Christopher D. Fekete |
| collection | DOAJ |
| description | Myelination is critical for fast saltatory conduction of action potentials. Recent studies have revealed that myelin is not a static structure as previously considered but continues to be made and remodeled throughout adulthood in tune with the network requirement. Synthesis of new myelin requires turning on the switch in oligodendrocytes (OL) to initiate the myelination program that includes synthesis and transport of macromolecules needed for myelin production as well as the metabolic and other cellular functions needed to support this process. A significant amount of information is available regarding the individual intrinsic and extrinsic signals that promote OL commitment, expansion, terminal differentiation, and myelination. However, it is less clear how these signals are made available to OL lineage cells when needed, and how multiple signals are integrated to generate the correct amount of myelin that is needed in a given neural network state. Here we review the pleiotropic effects of some of the extracellular signals that affect myelination and discuss the cellular processes used by the source cells that contribute to the variation in the temporal and spatial availability of the signals, and how the recipient OL lineage cells might integrate the multiple signals presented to them in a manner dialed to the strength of the input. |
| first_indexed | 2024-04-13T20:43:02Z |
| format | Article |
| id | doaj.art-e46b18354dec4ad9afccdced240dbdca |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T20:43:02Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-e46b18354dec4ad9afccdced240dbdca2022-12-22T02:30:48ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-11-011610.3389/fncel.2022.10418531041853Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelinationChristopher D. FeketeAkiko NishiyamaMyelination is critical for fast saltatory conduction of action potentials. Recent studies have revealed that myelin is not a static structure as previously considered but continues to be made and remodeled throughout adulthood in tune with the network requirement. Synthesis of new myelin requires turning on the switch in oligodendrocytes (OL) to initiate the myelination program that includes synthesis and transport of macromolecules needed for myelin production as well as the metabolic and other cellular functions needed to support this process. A significant amount of information is available regarding the individual intrinsic and extrinsic signals that promote OL commitment, expansion, terminal differentiation, and myelination. However, it is less clear how these signals are made available to OL lineage cells when needed, and how multiple signals are integrated to generate the correct amount of myelin that is needed in a given neural network state. Here we review the pleiotropic effects of some of the extracellular signals that affect myelination and discuss the cellular processes used by the source cells that contribute to the variation in the temporal and spatial availability of the signals, and how the recipient OL lineage cells might integrate the multiple signals presented to them in a manner dialed to the strength of the input.https://www.frontiersin.org/articles/10.3389/fncel.2022.1041853/fulloligodendrocyteOPCNG2neuron-glia communicationtraffickingFyn |
| spellingShingle | Christopher D. Fekete Akiko Nishiyama Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination Frontiers in Cellular Neuroscience oligodendrocyte OPC NG2 neuron-glia communication trafficking Fyn |
| title | Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| title_full | Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| title_fullStr | Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| title_full_unstemmed | Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| title_short | Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| title_sort | presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination |
| topic | oligodendrocyte OPC NG2 neuron-glia communication trafficking Fyn |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.1041853/full |
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