Early congenital syphilis: solved and unresolved problems of diagnosis
Objective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 ne...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2019-05-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/860 |
| _version_ | 1797875207919108096 |
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| author | N. V. Matyskina T. E. Taranushenko |
| author_facet | N. V. Matyskina T. E. Taranushenko |
| author_sort | N. V. Matyskina |
| collection | DOAJ |
| description | Objective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 newborns born to women with a syphilitic infection. Results. The diagnostic sensitivity of the enzyme immunoassay with the determination of specific IgM was 86.6%, the polymerase chain reaction with the detection of Treponema pallidum DNA was 91.6%. Conclusion. The examination of newborns from mothers with a syphilitic infection can be optimized by reducing the number of laboratory techniques (microprecipitation reaction and passive haemagglutination reaction), subject to the mandatory determination of specific IgM and IgG in the first day of life, followed by further confirmation of diagnostics (IgG titer dynamics and the determination of the presence of T. pallidum DNA, as well as instrumental methods of research). |
| first_indexed | 2024-04-10T01:43:58Z |
| format | Article |
| id | doaj.art-e46b367bbf0a446d91eb72f39a74eb4a |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:43:58Z |
| publishDate | 2019-05-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-e46b367bbf0a446d91eb72f39a74eb4a2023-03-13T09:12:46ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282019-05-01642758010.21508/1027-4065-2019-64-2-75-80721Early congenital syphilis: solved and unresolved problems of diagnosisN. V. Matyskina0T. E. Taranushenko1ФГБОУ ВО «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Минздрава РоссииФГБОУ ВО «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Минздрава РоссииObjective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 newborns born to women with a syphilitic infection. Results. The diagnostic sensitivity of the enzyme immunoassay with the determination of specific IgM was 86.6%, the polymerase chain reaction with the detection of Treponema pallidum DNA was 91.6%. Conclusion. The examination of newborns from mothers with a syphilitic infection can be optimized by reducing the number of laboratory techniques (microprecipitation reaction and passive haemagglutination reaction), subject to the mandatory determination of specific IgM and IgG in the first day of life, followed by further confirmation of diagnostics (IgG titer dynamics and the determination of the presence of T. pallidum DNA, as well as instrumental methods of research).https://www.ped-perinatology.ru/jour/article/view/860детиноворожденныеранний врожденный сифилислабораторная диагностикаспецифические igm и iggполимеразная цепная реакция |
| spellingShingle | N. V. Matyskina T. E. Taranushenko Early congenital syphilis: solved and unresolved problems of diagnosis Rossijskij Vestnik Perinatologii i Pediatrii дети новорожденные ранний врожденный сифилис лабораторная диагностика специфические igm и igg полимеразная цепная реакция |
| title | Early congenital syphilis: solved and unresolved problems of diagnosis |
| title_full | Early congenital syphilis: solved and unresolved problems of diagnosis |
| title_fullStr | Early congenital syphilis: solved and unresolved problems of diagnosis |
| title_full_unstemmed | Early congenital syphilis: solved and unresolved problems of diagnosis |
| title_short | Early congenital syphilis: solved and unresolved problems of diagnosis |
| title_sort | early congenital syphilis solved and unresolved problems of diagnosis |
| topic | дети новорожденные ранний врожденный сифилис лабораторная диагностика специфические igm и igg полимеразная цепная реакция |
| url | https://www.ped-perinatology.ru/jour/article/view/860 |
| work_keys_str_mv | AT nvmatyskina earlycongenitalsyphilissolvedandunresolvedproblemsofdiagnosis AT tetaranushenko earlycongenitalsyphilissolvedandunresolvedproblemsofdiagnosis |