A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis
White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=217;epage=221;aulast=Lee |
| _version_ | 1818200012644941824 |
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| author | Aejin Lee Ouliana Ziouzenkova |
| author_facet | Aejin Lee Ouliana Ziouzenkova |
| author_sort | Aejin Lee |
| collection | DOAJ |
| description | White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. According to a current paradigm, multilocular adipocytes have a thermogenic function in WAT. In this mini review, we discuss data revealing heterogeneity among multilocular cell subsets in WAT and their functions beyond thermogenesis. We propose a hypothetical neuroendocrine role for multilocular adipocytes subsets in the formation of adaptive sensory-sympathetic circuits between the central nervous system and adipose tissue, which activate lipolysis and thermogenesis in WAT in high energy demand situations. |
| first_indexed | 2024-12-12T02:30:54Z |
| format | Article |
| id | doaj.art-e46ca9df075041e3be1fcc2156628913 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T02:30:54Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-e46ca9df075041e3be1fcc21566289132022-12-22T00:41:25ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742019-01-0114221722110.4103/1673-5374.244777A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesisAejin LeeOuliana ZiouzenkovaWhite adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. According to a current paradigm, multilocular adipocytes have a thermogenic function in WAT. In this mini review, we discuss data revealing heterogeneity among multilocular cell subsets in WAT and their functions beyond thermogenesis. We propose a hypothetical neuroendocrine role for multilocular adipocytes subsets in the formation of adaptive sensory-sympathetic circuits between the central nervous system and adipose tissue, which activate lipolysis and thermogenesis in WAT in high energy demand situations.http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=217;epage=221;aulast=Leeobesity; thermogenesis; innervation; vitamin A; aldehyde dehydrogenase; paracrine; efferent; afferent; brown adipose tissue |
| spellingShingle | Aejin Lee Ouliana Ziouzenkova A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis Neural Regeneration Research obesity; thermogenesis; innervation; vitamin A; aldehyde dehydrogenase; paracrine; efferent; afferent; brown adipose tissue |
| title | A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis |
| title_full | A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis |
| title_fullStr | A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis |
| title_full_unstemmed | A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis |
| title_short | A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis |
| title_sort | paracrine role for white thermogenic adipocytes in innervation an evidence based hypothesis |
| topic | obesity; thermogenesis; innervation; vitamin A; aldehyde dehydrogenase; paracrine; efferent; afferent; brown adipose tissue |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=217;epage=221;aulast=Lee |
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