Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data

Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data

Ribozymes are RNA molecules that catalyze biochemical reactions. Self-cleaving ribozymes are a common naturally occurring class of ribozymes that catalyze site-specific cleavage of their own phosphodiester backbone. In addition to their natural functions, self-cleaving ribozymes have been used to en...

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Bibliographic Details
Main Authors: James D. Beck, Jessica M. Roberts, Joey M. Kitzhaber, Ashlyn Trapp, Edoardo Serra, Francesca Spezzano, Eric J. Hayden
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
ribozyme
fitness landscape
RNA
epistasis
machine learning
long short-term memory
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.893864/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.893864/full

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