Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study
Metabolic syndrome (MetSyn) has a rapidly growing worldwide prevalence, affecting over 1 billion people. MetSyn is clustering many pathological conditions, which, untreated, could increase the risk and often lead to more severe metabolic defects such as type 2 diabetes and non-alcoholic fatty liver...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/3/218 |
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| author | Gratiela Gradisteanu Pircalabioru Iuliana Ilie Luciana Oprea Ariana Picu Laura Madalina Petcu Liliana Burlibasa Mariana-Carmen Chifiriuc Madalina Musat |
| author_facet | Gratiela Gradisteanu Pircalabioru Iuliana Ilie Luciana Oprea Ariana Picu Laura Madalina Petcu Liliana Burlibasa Mariana-Carmen Chifiriuc Madalina Musat |
| author_sort | Gratiela Gradisteanu Pircalabioru |
| collection | DOAJ |
| description | Metabolic syndrome (MetSyn) has a rapidly growing worldwide prevalence, affecting over 1 billion people. MetSyn is clustering many pathological conditions, which, untreated, could increase the risk and often lead to more severe metabolic defects such as type 2 diabetes and non-alcoholic fatty liver disease. Many data demonstrate the complex role of gut microbiota in the host metabolism, and hence, deciphering the microbiome patterns linked to MetSyn could enable us for novel diagnosis and monitoring markers and for better disease management. Moreover, interventions designed to alter patient microbiome composition may help prevent or decrease morbidity linked with MetSyn. However, the microbiome composition is largely different across geographically distinct populations. Our study investigated the microbiota and mycobiome patterns in Romanian metabolic syndrome patients. We also correlated the identified microbiome–mycobiome patterns with levels of metabolites important for host health such as short chain fatty acids, organic acids, and taurine. We found that MetSyn patients are harboring a microbiome enriched in <i>Enterobacteriaceae</i>, <i>Turicibacter</i> sp., <i>Clostridium coccoides,</i> and <i>Clostridium leptum,</i> while beneficial taxa such as <i>Butyricicoccus</i> sp., <i>Akkermansia muciniphila</i>, and <i>Faecalibacterium prausnitzii</i> were decreased. These microbiome changes were correlated with lower butyrate levels and increased succinate. In terms of mycobiome signatures, MetSyn was associated with a high abundance of <i>Saccharomyces</i> and <i>Aspergillus</i> species. Our data are the first reported on a Romanian population and confirming that the pathogenesis of MetSyn is closely related to gut microbiome and homeostasis. |
| first_indexed | 2024-03-09T13:21:51Z |
| format | Article |
| id | doaj.art-e4700586e3484980afab51bc64e5163f |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T13:21:51Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-e4700586e3484980afab51bc64e5163f2023-11-30T21:29:30ZengMDPI AGMetabolites2218-19892022-02-0112321810.3390/metabo12030218Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot StudyGratiela Gradisteanu Pircalabioru0Iuliana Ilie1Luciana Oprea2Ariana Picu3Laura Madalina Petcu4Liliana Burlibasa5Mariana-Carmen Chifiriuc6Madalina Musat7Research Institute of University of Bucharest (ICUB), 050095 Bucharest, RomaniaGral Medical Clinic, 031424 Bucharest, RomaniaNational Institute of Endocrinology C.I. Parhon, 011863 Bucharest, RomaniaResearch Institute of University of Bucharest (ICUB), 050095 Bucharest, RomaniaResearch Institute of University of Bucharest (ICUB), 050095 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaResearch Institute of University of Bucharest (ICUB), 050095 Bucharest, RomaniaNational Institute of Endocrinology C.I. Parhon, 011863 Bucharest, RomaniaMetabolic syndrome (MetSyn) has a rapidly growing worldwide prevalence, affecting over 1 billion people. MetSyn is clustering many pathological conditions, which, untreated, could increase the risk and often lead to more severe metabolic defects such as type 2 diabetes and non-alcoholic fatty liver disease. Many data demonstrate the complex role of gut microbiota in the host metabolism, and hence, deciphering the microbiome patterns linked to MetSyn could enable us for novel diagnosis and monitoring markers and for better disease management. Moreover, interventions designed to alter patient microbiome composition may help prevent or decrease morbidity linked with MetSyn. However, the microbiome composition is largely different across geographically distinct populations. Our study investigated the microbiota and mycobiome patterns in Romanian metabolic syndrome patients. We also correlated the identified microbiome–mycobiome patterns with levels of metabolites important for host health such as short chain fatty acids, organic acids, and taurine. We found that MetSyn patients are harboring a microbiome enriched in <i>Enterobacteriaceae</i>, <i>Turicibacter</i> sp., <i>Clostridium coccoides,</i> and <i>Clostridium leptum,</i> while beneficial taxa such as <i>Butyricicoccus</i> sp., <i>Akkermansia muciniphila</i>, and <i>Faecalibacterium prausnitzii</i> were decreased. These microbiome changes were correlated with lower butyrate levels and increased succinate. In terms of mycobiome signatures, MetSyn was associated with a high abundance of <i>Saccharomyces</i> and <i>Aspergillus</i> species. Our data are the first reported on a Romanian population and confirming that the pathogenesis of MetSyn is closely related to gut microbiome and homeostasis.https://www.mdpi.com/2218-1989/12/3/218metabolic syndromemicrobiomemicrobiotamycobiomemetabolome |
| spellingShingle | Gratiela Gradisteanu Pircalabioru Iuliana Ilie Luciana Oprea Ariana Picu Laura Madalina Petcu Liliana Burlibasa Mariana-Carmen Chifiriuc Madalina Musat Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study Metabolites metabolic syndrome microbiome microbiota mycobiome metabolome |
| title | Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study |
| title_full | Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study |
| title_fullStr | Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study |
| title_full_unstemmed | Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study |
| title_short | Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome—A Pilot Study |
| title_sort | microbiome mycobiome and related metabolites alterations in patients with metabolic syndrome a pilot study |
| topic | metabolic syndrome microbiome microbiota mycobiome metabolome |
| url | https://www.mdpi.com/2218-1989/12/3/218 |
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