Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol
Abstract Background Symptom burden and adverse treatment effects can negatively impact physical function, health-related outcomes, and quality of life in cancer survivors. Resistive exercise that improves skeletal muscle function can ameliorate these complications, but the central role of the skelet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-022-02130-z |
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| author | Jacqueline K. Dawson Dong-Woo Kang Oscar Barnes Rebekah L. Wilson Mary K. Norris Christina M. Dieli-Conwright |
| author_facet | Jacqueline K. Dawson Dong-Woo Kang Oscar Barnes Rebekah L. Wilson Mary K. Norris Christina M. Dieli-Conwright |
| author_sort | Jacqueline K. Dawson |
| collection | DOAJ |
| description | Abstract Background Symptom burden and adverse treatment effects can negatively impact physical function, health-related outcomes, and quality of life in cancer survivors. Resistive exercise that improves skeletal muscle function can ameliorate these complications, but the central role of the skeletal muscle in mediating improvements in patient-related outcomes has not been explored. This protocol describes the rationale and methods for a systematic review that aims to determine the effects of resistive exercise on the skeletal muscle hypertrophy, muscle performance, and muscle-related biomarkers in cancer survivors. Methods A systematic review will be conducted on peer-reviewed randomized controlled trials (RCTs) that employ resistive exercise interventions for cancer survivors. The following electronic databases will be searched: AMED, CENTRAL, CINAHL, CIRRIE, EMBASE, MEDLINE, PEDro, REHABDATA, Scopus, and SPORTDiscus. Studies will be considered for inclusion if they present quantitative data in adult cancer survivors on skeletal muscle characteristics (e.g., muscle mass), muscle performance (e.g., strength), or skeletal muscle-related biomarkers (e.g., myocellular satellite cells). Secondary outcomes will be physical function (e.g., stair climb) and patient-reported outcomes (e.g., fatigue). Data will be reported through a narrative that describes study design, participants, interventions, and outcome characteristics. Discussion This systematic review will help clarify the influence of resistive exercise on factors relating to the skeletal muscle in adult cancer survivors. Findings may provide insight into optimal exercise selection for evidence-based practice. Systematic review registration PROSPERO: #277791 [under review] |
| first_indexed | 2024-04-13T08:08:35Z |
| format | Article |
| id | doaj.art-e471ea72a26a4886b609de3f7391fa31 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-04-13T08:08:35Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-e471ea72a26a4886b609de3f7391fa312022-12-22T02:55:06ZengBMCSystematic Reviews2046-40532022-11-011111610.1186/s13643-022-02130-zEfficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocolJacqueline K. Dawson0Dong-Woo Kang1Oscar Barnes2Rebekah L. Wilson3Mary K. Norris4Christina M. Dieli-Conwright5Department of Physical Therapy, California State UniversityDivision of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer InstituteGreen Templeton College, University of OxfordDivision of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer InstituteDivision of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer InstituteDivision of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer InstituteAbstract Background Symptom burden and adverse treatment effects can negatively impact physical function, health-related outcomes, and quality of life in cancer survivors. Resistive exercise that improves skeletal muscle function can ameliorate these complications, but the central role of the skeletal muscle in mediating improvements in patient-related outcomes has not been explored. This protocol describes the rationale and methods for a systematic review that aims to determine the effects of resistive exercise on the skeletal muscle hypertrophy, muscle performance, and muscle-related biomarkers in cancer survivors. Methods A systematic review will be conducted on peer-reviewed randomized controlled trials (RCTs) that employ resistive exercise interventions for cancer survivors. The following electronic databases will be searched: AMED, CENTRAL, CINAHL, CIRRIE, EMBASE, MEDLINE, PEDro, REHABDATA, Scopus, and SPORTDiscus. Studies will be considered for inclusion if they present quantitative data in adult cancer survivors on skeletal muscle characteristics (e.g., muscle mass), muscle performance (e.g., strength), or skeletal muscle-related biomarkers (e.g., myocellular satellite cells). Secondary outcomes will be physical function (e.g., stair climb) and patient-reported outcomes (e.g., fatigue). Data will be reported through a narrative that describes study design, participants, interventions, and outcome characteristics. Discussion This systematic review will help clarify the influence of resistive exercise on factors relating to the skeletal muscle in adult cancer survivors. Findings may provide insight into optimal exercise selection for evidence-based practice. Systematic review registration PROSPERO: #277791 [under review]https://doi.org/10.1186/s13643-022-02130-zOncologyResistance exerciseMuscle performanceMuscle hypertrophyMuscle-related biomarkersCancer patients |
| spellingShingle | Jacqueline K. Dawson Dong-Woo Kang Oscar Barnes Rebekah L. Wilson Mary K. Norris Christina M. Dieli-Conwright Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol Systematic Reviews Oncology Resistance exercise Muscle performance Muscle hypertrophy Muscle-related biomarkers Cancer patients |
| title | Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol |
| title_full | Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol |
| title_fullStr | Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol |
| title_full_unstemmed | Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol |
| title_short | Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol |
| title_sort | efficacy of resistive exercise on skeletal muscle related outcomes in cancer survivors a systematic review protocol |
| topic | Oncology Resistance exercise Muscle performance Muscle hypertrophy Muscle-related biomarkers Cancer patients |
| url | https://doi.org/10.1186/s13643-022-02130-z |
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