Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer
The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic developme...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12270 |
| _version_ | 1797431591165755392 |
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| author | Wei Wang Xiangjun Wang Feng Yao Chao Huang |
| author_facet | Wei Wang Xiangjun Wang Feng Yao Chao Huang |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic development, and wound healing. Recent studies have found the aberrant expression or activity of the LOX family occurs in various types of cancer. It has been proved that the LOX family mainly performs tumor microenvironment (TME) remodeling function and is extensively involved in tumor invasion and metastasis, immunomodulation, proliferation, apoptosis, etc. With relevant translational research in progress, the LOX family is expected to be an effective target for tumor therapy. Here, we review the research progress of the LOX family in tumor progression and therapy to provide novel insights for future exploration of relevant tumor mechanism and new therapeutic targets. |
| first_indexed | 2024-03-09T09:47:22Z |
| format | Article |
| id | doaj.art-e472559199a94276977b4867c11f0460 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T09:47:22Z |
| publishDate | 2022-10-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e472559199a94276977b4867c11f04602023-12-02T00:31:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201227010.3390/ijms232012270Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in CancerWei Wang0Xiangjun Wang1Feng Yao2Chao Huang3Department of Hepatobiliary and Pancreatic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaThoracic Oncology Institute, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Cell Biology, Medical School, Kunming University of Science and Technology, Kunming 650500, ChinaThe lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic development, and wound healing. Recent studies have found the aberrant expression or activity of the LOX family occurs in various types of cancer. It has been proved that the LOX family mainly performs tumor microenvironment (TME) remodeling function and is extensively involved in tumor invasion and metastasis, immunomodulation, proliferation, apoptosis, etc. With relevant translational research in progress, the LOX family is expected to be an effective target for tumor therapy. Here, we review the research progress of the LOX family in tumor progression and therapy to provide novel insights for future exploration of relevant tumor mechanism and new therapeutic targets.https://www.mdpi.com/1422-0067/23/20/12270lysyl oxidase (LOX)extracellular matrix (ECM)cancerLOX family |
| spellingShingle | Wei Wang Xiangjun Wang Feng Yao Chao Huang Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer International Journal of Molecular Sciences lysyl oxidase (LOX) extracellular matrix (ECM) cancer LOX family |
| title | Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer |
| title_full | Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer |
| title_fullStr | Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer |
| title_full_unstemmed | Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer |
| title_short | Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer |
| title_sort | lysyl oxidase family proteins prospective therapeutic targets in cancer |
| topic | lysyl oxidase (LOX) extracellular matrix (ECM) cancer LOX family |
| url | https://www.mdpi.com/1422-0067/23/20/12270 |
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