Effect of COVID-19 on Kidney Graft Function One Year after Onset
<i>Background and Objectives:</i> Kidney transplant recipients (KTRs) are at a higher risk of severe COVID-19 development. The course of the infection may vary. Long-term consequences for graft function are still being studied. We investigate whether the clinical course of SARS-CoV-2 inf...
| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
MDPI AG
2023-12-01
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| coleção: | Medicina |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1648-9144/60/1/26 |
| _version_ | 1827371530536878080 |
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| author | Agnieszka Malinowska Jakub Ruszkowski Marta Muchlado Zuzanna Ślizień Zbigniew Heleniak Aleksandra Parczewska Katarzyna Kanclerz Bogdan Biedunkiewicz Leszek Tylicki Ewa Król Alicja Dębska-Ślizień |
| author_facet | Agnieszka Malinowska Jakub Ruszkowski Marta Muchlado Zuzanna Ślizień Zbigniew Heleniak Aleksandra Parczewska Katarzyna Kanclerz Bogdan Biedunkiewicz Leszek Tylicki Ewa Król Alicja Dębska-Ślizień |
| author_sort | Agnieszka Malinowska |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Kidney transplant recipients (KTRs) are at a higher risk of severe COVID-19 development. The course of the infection may vary. Long-term consequences for graft function are still being studied. We investigate whether the clinical course of SARS-CoV-2 infection among KTRs had a long-term effect on graft function. <i>Patients and method:</i> 128 KTRs with confirmed SARS-CoV-2 infection were included in the study. They were divided into two groups: mild (without the need for oxygen therapy; <i>n</i> = 91) and severe (with the need for oxygen therapy; <i>n</i> = 21). Baseline characteristics and medical data, especially creatinine level, estimated glomerular filtration rate (eGFR) CKD-EPI, and proteinuria, were analyzed. The main outcomes were the absolute and relative change in eGFR during the one-year follow-up after COVID-19. In the final models, sex, age, smoking, presence of diabetes mellitus (DM), and cardiovascular disease (CVD) were included. <i>Results:</i> KTRs with severe COVID-19 were older, more likely to smoke, and had DM and CVD more frequently. Our analysis reveals that COVID-19 severity was associated with a significantly more pronounced relative eGFR decline one year after recovery only in males [−13.94 (95% CI: −25.13 to −2.76, <i>p</i> = 0.015) percentage points]. One year after the disease onset, males with a severe course of the infection had a higher eGFR decline than those with a mild one. The COVID-19 severity did not affect eGFR loss in females. <i>Conclusions:</i> In KTRs suffering from COVID-19, deterioration of graft function was noticed. The eGFR decline was associated with disease severity and sex. It indicates a need for further research, observation, and preventive actions for KTRs, especially males. |
| first_indexed | 2024-03-08T10:41:45Z |
| format | Article |
| id | doaj.art-e472db6d9eec451598ef2892c1fc6821 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:45Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e472db6d9eec451598ef2892c1fc68212024-01-26T17:34:55ZengMDPI AGMedicina1010-660X1648-91442023-12-016012610.3390/medicina60010026Effect of COVID-19 on Kidney Graft Function One Year after OnsetAgnieszka Malinowska0Jakub Ruszkowski1Marta Muchlado2Zuzanna Ślizień3Zbigniew Heleniak4Aleksandra Parczewska5Katarzyna Kanclerz6Bogdan Biedunkiewicz7Leszek Tylicki8Ewa Król9Alicja Dębska-Ślizień10Department of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, Poland7th Naval Hospital in Gdansk, 80-305 Gdansk, PolandDepartment of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, Poland<i>Background and Objectives:</i> Kidney transplant recipients (KTRs) are at a higher risk of severe COVID-19 development. The course of the infection may vary. Long-term consequences for graft function are still being studied. We investigate whether the clinical course of SARS-CoV-2 infection among KTRs had a long-term effect on graft function. <i>Patients and method:</i> 128 KTRs with confirmed SARS-CoV-2 infection were included in the study. They were divided into two groups: mild (without the need for oxygen therapy; <i>n</i> = 91) and severe (with the need for oxygen therapy; <i>n</i> = 21). Baseline characteristics and medical data, especially creatinine level, estimated glomerular filtration rate (eGFR) CKD-EPI, and proteinuria, were analyzed. The main outcomes were the absolute and relative change in eGFR during the one-year follow-up after COVID-19. In the final models, sex, age, smoking, presence of diabetes mellitus (DM), and cardiovascular disease (CVD) were included. <i>Results:</i> KTRs with severe COVID-19 were older, more likely to smoke, and had DM and CVD more frequently. Our analysis reveals that COVID-19 severity was associated with a significantly more pronounced relative eGFR decline one year after recovery only in males [−13.94 (95% CI: −25.13 to −2.76, <i>p</i> = 0.015) percentage points]. One year after the disease onset, males with a severe course of the infection had a higher eGFR decline than those with a mild one. The COVID-19 severity did not affect eGFR loss in females. <i>Conclusions:</i> In KTRs suffering from COVID-19, deterioration of graft function was noticed. The eGFR decline was associated with disease severity and sex. It indicates a need for further research, observation, and preventive actions for KTRs, especially males.https://www.mdpi.com/1648-9144/60/1/26COVID-19graft functionkidney transplant recipients |
| spellingShingle | Agnieszka Malinowska Jakub Ruszkowski Marta Muchlado Zuzanna Ślizień Zbigniew Heleniak Aleksandra Parczewska Katarzyna Kanclerz Bogdan Biedunkiewicz Leszek Tylicki Ewa Król Alicja Dębska-Ślizień Effect of COVID-19 on Kidney Graft Function One Year after Onset Medicina COVID-19 graft function kidney transplant recipients |
| title | Effect of COVID-19 on Kidney Graft Function One Year after Onset |
| title_full | Effect of COVID-19 on Kidney Graft Function One Year after Onset |
| title_fullStr | Effect of COVID-19 on Kidney Graft Function One Year after Onset |
| title_full_unstemmed | Effect of COVID-19 on Kidney Graft Function One Year after Onset |
| title_short | Effect of COVID-19 on Kidney Graft Function One Year after Onset |
| title_sort | effect of covid 19 on kidney graft function one year after onset |
| topic | COVID-19 graft function kidney transplant recipients |
| url | https://www.mdpi.com/1648-9144/60/1/26 |
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