Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23595-x |
| _version_ | 1818736206920286208 |
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| author | Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen |
| author_facet | Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen |
| author_sort | Yue Li |
| collection | DOAJ |
| description | Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice. |
| first_indexed | 2024-12-18T00:33:28Z |
| format | Article |
| id | doaj.art-e474110267a740bcbae71a2b1885f9cd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:33:28Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e474110267a740bcbae71a2b1885f9cd2022-12-21T21:27:05ZengNature PortfolioNature Communications2041-17232021-06-0112111410.1038/s41467-021-23595-xThioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in miceYue Li0Norihiro Imai1Hayley T. Nicholls2Blaine R. Roberts3Samaksh Goyal4Tibor I. Krisko5Lay-Hong Ang6Matthew C. Tillman7Anne M. Roberts8Mahnoor Baqai9Eric A. Ortlund10David E. Cohen11Susan J. Hagen12Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical CenterDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical CollegeDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical CollegeDepartment of Biochemistry, Emory UniversityDivision of General Surgery, Department of Surgery, Beth Israel Deaconess Medical CenterDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical CollegeDivision of General Surgery, Department of Surgery, Beth Israel Deaconess Medical CenterDepartment of Biochemistry, Emory UniversityDepartment of Biochemistry, Emory UniversityDivision of General Surgery, Department of Surgery, Beth Israel Deaconess Medical CenterDepartment of Biochemistry, Emory UniversityDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical CollegeDivision of General Surgery, Department of Surgery, Beth Israel Deaconess Medical CenterCold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.https://doi.org/10.1038/s41467-021-23595-x |
| spellingShingle | Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice Nature Communications |
| title | Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice |
| title_full | Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice |
| title_fullStr | Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice |
| title_full_unstemmed | Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice |
| title_short | Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice |
| title_sort | thioesterase superfamily member 1 undergoes stimulus coupled conformational reorganization to regulate metabolism in mice |
| url | https://doi.org/10.1038/s41467-021-23595-x |
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