Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective
The number of depressed patients treated with deep brain stimulation is relatively small. However, experience with this intervention now spans more than 10 years at some centers, with study subjects typically monitored closely. Here we describe one center’s evolving impressions regarding optimal pat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00041/full |
| _version_ | 1818039091123453952 |
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| author | Andrea L Crowell Steven J Garlow Patricio eRiva Posse Helen S Mayberg Helen S Mayberg |
| author_facet | Andrea L Crowell Steven J Garlow Patricio eRiva Posse Helen S Mayberg Helen S Mayberg |
| author_sort | Andrea L Crowell |
| collection | DOAJ |
| description | The number of depressed patients treated with deep brain stimulation is relatively small. However, experience with this intervention now spans more than 10 years at some centers, with study subjects typically monitored closely. Here we describe one center’s evolving impressions regarding optimal patient selection for deep brain stimulation of the subcallosal cingulate as well as observations of short- and long-term patterns in antidepressant response and mood reactivity. A consistent time course of therapeutic response with distinct behavioral phases is observed. Early phases are characterized by changes in mood reactivity and a transient and predictable worsening in self ratings prior to stabilization of response. It is hypothesized that this characteristic recovery curve reflects the timeline of neuroplasticity in response to DBS. Further investigation of these emerging predictable psychiatric, biological, and psychosocial patterns will both improve treatment optimization and enhance understanding and recognition of meaningful DBS antidepressant effects. |
| first_indexed | 2024-12-10T07:53:07Z |
| format | Article |
| id | doaj.art-e476ea67b1894aa58e6374fa6554741f |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-12-10T07:53:07Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-e476ea67b1894aa58e6374fa6554741f2022-12-22T01:56:58ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452015-06-01910.3389/fnint.2015.00041141851Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspectiveAndrea L Crowell0Steven J Garlow1Patricio eRiva Posse2Helen S Mayberg3Helen S Mayberg4Emory University School of MedicineEmory University School of MedicineEmory University School of MedicineEmory University School of MedicineEmory University School of MedicineThe number of depressed patients treated with deep brain stimulation is relatively small. However, experience with this intervention now spans more than 10 years at some centers, with study subjects typically monitored closely. Here we describe one center’s evolving impressions regarding optimal patient selection for deep brain stimulation of the subcallosal cingulate as well as observations of short- and long-term patterns in antidepressant response and mood reactivity. A consistent time course of therapeutic response with distinct behavioral phases is observed. Early phases are characterized by changes in mood reactivity and a transient and predictable worsening in self ratings prior to stabilization of response. It is hypothesized that this characteristic recovery curve reflects the timeline of neuroplasticity in response to DBS. Further investigation of these emerging predictable psychiatric, biological, and psychosocial patterns will both improve treatment optimization and enhance understanding and recognition of meaningful DBS antidepressant effects.http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00041/fullDeep Brain Stimulationemotional reactivitytreatment resistant depressionsubcallosal cingulatetherapeutic course |
| spellingShingle | Andrea L Crowell Steven J Garlow Patricio eRiva Posse Helen S Mayberg Helen S Mayberg Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective Frontiers in Integrative Neuroscience Deep Brain Stimulation emotional reactivity treatment resistant depression subcallosal cingulate therapeutic course |
| title | Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective |
| title_full | Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective |
| title_fullStr | Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective |
| title_full_unstemmed | Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective |
| title_short | Characterizing the therapeutic response to deep brain stimulation for treatment resistant depression: a single center long-term perspective |
| title_sort | characterizing the therapeutic response to deep brain stimulation for treatment resistant depression a single center long term perspective |
| topic | Deep Brain Stimulation emotional reactivity treatment resistant depression subcallosal cingulate therapeutic course |
| url | http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00041/full |
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