Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS
To monitor national antimicrobial resistance (AMR), the Korea Global AMR Surveillance System (Kor-GLASS) was established. This study analyzed bloodstream infection (BSI) cases from Kor-GLASS phase I from January 2017 to December 2019. Nine non-duplicated Kor-GLASS target pathogens, including Staphyl...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.799084/full |
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| author | Dokyun Kim Eun-Jeong Yoon Eun-Jeong Yoon Jun Sung Hong Min Hyuk Choi Hyun Soo Kim Young Ree Kim Young Ah Kim Young Uh Kyeong Seob Shin Jeong Hwan Shin Jeong Su Park Kyoung Un Park Eun Jeong Won Soo Hyun Kim Jong Hee Shin Jung Wook Kim SungYoung Lee Seok Hoon Jeong |
| author_facet | Dokyun Kim Eun-Jeong Yoon Eun-Jeong Yoon Jun Sung Hong Min Hyuk Choi Hyun Soo Kim Young Ree Kim Young Ah Kim Young Uh Kyeong Seob Shin Jeong Hwan Shin Jeong Su Park Kyoung Un Park Eun Jeong Won Soo Hyun Kim Jong Hee Shin Jung Wook Kim SungYoung Lee Seok Hoon Jeong |
| author_sort | Dokyun Kim |
| collection | DOAJ |
| description | To monitor national antimicrobial resistance (AMR), the Korea Global AMR Surveillance System (Kor-GLASS) was established. This study analyzed bloodstream infection (BSI) cases from Kor-GLASS phase I from January 2017 to December 2019. Nine non-duplicated Kor-GLASS target pathogens, including Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter spp., and Salmonella spp., were isolated from blood specimens from eight sentinel hospitals. Antimicrobial susceptibility testing, AMR genotyping, and strain typing were carried out. Among the 20,041 BSI cases, 15,171 cases were caused by one of the target pathogens, and 12,578 blood isolates were collected for the study. Half (1,059/2,134) of S. aureus isolates were resistant to cefoxitin, and 38.1% (333/873) of E. faecium isolates were resistant to vancomycin. Beta-lactamase-non-producing ampicillin-resistant and penicillin-resistant E. faecalis isolates by disk diffusion method were identified, but the isolates were confirmed as ampicillin-susceptible by broth microdilution method. Among E. coli, an increasing number of isolates carried the blaCTX–M–27 gene, and the ertapenem resistance in 1.4% (30/2,110) of K. pneumoniae isolates was mostly (23/30) conferred by K. pneumoniae carbapenemases. A quarter (108/488) of P. aeruginosa isolates were resistant to meropenem, and 30.5% (33/108) of those carried acquired carbapenemase genes. Over 90% (542/599) of A. baumannii isolates were imipenem-resistant, and all except one harbored the blaOXA–23 gene. Kor-GLASS provided comprehensive AMR surveillance data, and the defined molecular mechanisms of resistance helped us to better understand AMR epidemiology. Comparative analysis with other GLASS-enrolled countries is possible owing to the harmonized system provided by GLASS. |
| first_indexed | 2024-12-24T01:34:15Z |
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| language | English |
| last_indexed | 2024-12-24T01:34:15Z |
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| spelling | doaj.art-e47962362f7f4848a16ef503937e900c2022-12-21T17:22:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-01-011210.3389/fmicb.2021.799084799084Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASSDokyun Kim0Eun-Jeong Yoon1Eun-Jeong Yoon2Jun Sung Hong3Min Hyuk Choi4Hyun Soo Kim5Young Ree Kim6Young Ah Kim7Young Uh8Kyeong Seob Shin9Jeong Hwan Shin10Jeong Su Park11Kyoung Un Park12Eun Jeong Won13Soo Hyun Kim14Jong Hee Shin15Jung Wook Kim16SungYoung Lee17Seok Hoon Jeong18Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South KoreaNational Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, South KoreaDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South KoreaDepartment of Laboratory Medicine, Jeju National University School of Medicine, Jeju, South KoreaDepartment of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South KoreaDepartment of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, South KoreaDepartment of Laboratory Medicine, College of Medicine, Chungbuk National University, Cheongju, South KoreaDepartment of Laboratory Medicine and Paik Institute for Clinical Research, Inje University College of Medicine, Busan, South KoreaDepartment of Laboratory Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Laboratory Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea0Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South Korea0Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South Korea0Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South KoreaNational Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, South KoreaNational Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, South KoreaDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South KoreaTo monitor national antimicrobial resistance (AMR), the Korea Global AMR Surveillance System (Kor-GLASS) was established. This study analyzed bloodstream infection (BSI) cases from Kor-GLASS phase I from January 2017 to December 2019. Nine non-duplicated Kor-GLASS target pathogens, including Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter spp., and Salmonella spp., were isolated from blood specimens from eight sentinel hospitals. Antimicrobial susceptibility testing, AMR genotyping, and strain typing were carried out. Among the 20,041 BSI cases, 15,171 cases were caused by one of the target pathogens, and 12,578 blood isolates were collected for the study. Half (1,059/2,134) of S. aureus isolates were resistant to cefoxitin, and 38.1% (333/873) of E. faecium isolates were resistant to vancomycin. Beta-lactamase-non-producing ampicillin-resistant and penicillin-resistant E. faecalis isolates by disk diffusion method were identified, but the isolates were confirmed as ampicillin-susceptible by broth microdilution method. Among E. coli, an increasing number of isolates carried the blaCTX–M–27 gene, and the ertapenem resistance in 1.4% (30/2,110) of K. pneumoniae isolates was mostly (23/30) conferred by K. pneumoniae carbapenemases. A quarter (108/488) of P. aeruginosa isolates were resistant to meropenem, and 30.5% (33/108) of those carried acquired carbapenemase genes. Over 90% (542/599) of A. baumannii isolates were imipenem-resistant, and all except one harbored the blaOXA–23 gene. Kor-GLASS provided comprehensive AMR surveillance data, and the defined molecular mechanisms of resistance helped us to better understand AMR epidemiology. Comparative analysis with other GLASS-enrolled countries is possible owing to the harmonized system provided by GLASS.https://www.frontiersin.org/articles/10.3389/fmicb.2021.799084/fullantimicrobial resistanceKor-GLASSWHOGLASSsurveillance |
| spellingShingle | Dokyun Kim Eun-Jeong Yoon Eun-Jeong Yoon Jun Sung Hong Min Hyuk Choi Hyun Soo Kim Young Ree Kim Young Ah Kim Young Uh Kyeong Seob Shin Jeong Hwan Shin Jeong Su Park Kyoung Un Park Eun Jeong Won Soo Hyun Kim Jong Hee Shin Jung Wook Kim SungYoung Lee Seok Hoon Jeong Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS Frontiers in Microbiology antimicrobial resistance Kor-GLASS WHO GLASS surveillance |
| title | Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS |
| title_full | Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS |
| title_fullStr | Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS |
| title_full_unstemmed | Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS |
| title_short | Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS |
| title_sort | major bloodstream infection causing bacterial pathogens and their antimicrobial resistance in south korea 2017 2019 phase i report from kor glass |
| topic | antimicrobial resistance Kor-GLASS WHO GLASS surveillance |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.799084/full |
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