Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia

Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia

Objective To investigate potential relationship between gene polymorphisms of ATP-binding cassette B1, C4 (ABCB1, ABCC4) and solute carrier organic anion transporter 1B1 gene(SLCO1B1) with methotrexate (MTX) blood drug concentration and high dose-MTX (HD-MTX)-related adverse events (AEs) in childhoo...

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Bibliographic Details
Main Author: TIAN Xiao-yi, LIU Ying, YAO Yao, GU Xiu-li, LI Ai-hua, ZHENG Hu-yong, SONG Wen-qi
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2022-05-01
Series:Jichu yixue yu linchuang
Subjects:
methotrexate (mtx)|childhood acute lymphoblastic leukemia (all)|gene polymorphisms|blood drug concentrations|adverse events
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-5-708.pdf

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http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-5-708.pdf

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