Perylene‐Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo‐Immunotherapy

Perylene‐Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo‐Immunotherapy

Abstract Perylene derivatives can be stimulated by the hypoxic tumor microenvironment to generate radical anion that is proposed to arouse electron exchange with oxidizing substance, and in turn, realize reactive oxygen species (ROS) burst. Here, three perylene therapeutic agents, PDI‐NI, PDIB‐NI, a...

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Bibliographic Details
Main Authors: Bianbian Zhang, Rijie Zheng, Yuting Liu, Xue Lou, Wei Zhang, Zhanjun Cui, Yongwei Huang, Tie Wang
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Advanced Science
Subjects:
chemo‐immunotherapy
endogenous reactive oxygen species burst
hypoxic tumor
immunogenic cell death
perylene
Online Access:https://doi.org/10.1002/advs.202204498

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