Optic disc and retinal vascular features in first 6 years of Chinese children
PurposeRetinal microvasculature plays an important role in children's fundus lesions and even in their later life. However, little was known on the features of normal retina in early life. The purpose of this study was to explore the normal retinal features in the first 6 years of life and prov...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1101768/full |
| _version_ | 1797861931042734080 |
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| author | Guina Liu Anna Jiang Le Cao Saiguang Ling Xi Wang Shaochong Bu Fang Lu |
| author_facet | Guina Liu Anna Jiang Le Cao Saiguang Ling Xi Wang Shaochong Bu Fang Lu |
| author_sort | Guina Liu |
| collection | DOAJ |
| description | PurposeRetinal microvasculature plays an important role in children's fundus lesions and even in their later life. However, little was known on the features of normal retina in early life. The purpose of this study was to explore the normal retinal features in the first 6 years of life and provide information for future research.MethodsChildren, aged from birth to 6 years old and diagnosed with various unilateral ocular diseases were included. Venous phase fundus fluorescein angiography images with the optic disc at the center were collected. Based on the ResUNet convolutional neural network, optic disc and retinal vascular features in the posterior retina were computed automatically.ResultsA total of 146 normal eyes of 146 children were included. Among different age groups, no changes were shown in the optic disc diameter (y = −0.00002x + 1.362, R2 = 0.025, p = 0.058). Retinal vessel density and fractal dimension are linearly and strongly correlated (r = 0.979, p < 0.001). Older children had smaller value of fractal dimension (y = −0.000026x + 1.549, R2 = 0.075, p = 0.001) and narrower vascular caliber if they were less than 3 years old (y = −0.008x + 84.861, R2 = 0.205, p < 0.001). No differences were in the density (y = −0.000007x + 0.134, R2 = 0.023, p = 0.067) and the curvature of retinal vessels (lnC = −0.00001x − 4.657, R2 = 0.001, p = 0.667).ConclusionsAge and gender did not impact the optic disc diameter, vessel density, and vessel curvature significantly in this group of children. Trends of decreased vessel caliber in the first 3 years of life and decreased vessel complexity with age were observed. The structural characteristics provide information for future research to better understand the developmental origin of the healthy and diseased retina. |
| first_indexed | 2024-04-09T22:12:17Z |
| format | Article |
| id | doaj.art-e47bea3cd54d43bcbd54c20d7aceb3fa |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T22:12:17Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-e47bea3cd54d43bcbd54c20d7aceb3fa2023-03-23T10:01:53ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11017681101768Optic disc and retinal vascular features in first 6 years of Chinese childrenGuina Liu0Anna Jiang1Le Cao2Saiguang Ling3Xi Wang4Shaochong Bu5Fang Lu6Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaEVision Technology (Beijing) Co. LTD, Beijing, ChinaEVision Technology (Beijing) Co. LTD, Beijing, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaPurposeRetinal microvasculature plays an important role in children's fundus lesions and even in their later life. However, little was known on the features of normal retina in early life. The purpose of this study was to explore the normal retinal features in the first 6 years of life and provide information for future research.MethodsChildren, aged from birth to 6 years old and diagnosed with various unilateral ocular diseases were included. Venous phase fundus fluorescein angiography images with the optic disc at the center were collected. Based on the ResUNet convolutional neural network, optic disc and retinal vascular features in the posterior retina were computed automatically.ResultsA total of 146 normal eyes of 146 children were included. Among different age groups, no changes were shown in the optic disc diameter (y = −0.00002x + 1.362, R2 = 0.025, p = 0.058). Retinal vessel density and fractal dimension are linearly and strongly correlated (r = 0.979, p < 0.001). Older children had smaller value of fractal dimension (y = −0.000026x + 1.549, R2 = 0.075, p = 0.001) and narrower vascular caliber if they were less than 3 years old (y = −0.008x + 84.861, R2 = 0.205, p < 0.001). No differences were in the density (y = −0.000007x + 0.134, R2 = 0.023, p = 0.067) and the curvature of retinal vessels (lnC = −0.00001x − 4.657, R2 = 0.001, p = 0.667).ConclusionsAge and gender did not impact the optic disc diameter, vessel density, and vessel curvature significantly in this group of children. Trends of decreased vessel caliber in the first 3 years of life and decreased vessel complexity with age were observed. The structural characteristics provide information for future research to better understand the developmental origin of the healthy and diseased retina.https://www.frontiersin.org/articles/10.3389/fped.2023.1101768/fulloptic discretinal vasculaturechildren’s visionartificial intelligenceretinal development |
| spellingShingle | Guina Liu Anna Jiang Le Cao Saiguang Ling Xi Wang Shaochong Bu Fang Lu Optic disc and retinal vascular features in first 6 years of Chinese children Frontiers in Pediatrics optic disc retinal vasculature children’s vision artificial intelligence retinal development |
| title | Optic disc and retinal vascular features in first 6 years of Chinese children |
| title_full | Optic disc and retinal vascular features in first 6 years of Chinese children |
| title_fullStr | Optic disc and retinal vascular features in first 6 years of Chinese children |
| title_full_unstemmed | Optic disc and retinal vascular features in first 6 years of Chinese children |
| title_short | Optic disc and retinal vascular features in first 6 years of Chinese children |
| title_sort | optic disc and retinal vascular features in first 6 years of chinese children |
| topic | optic disc retinal vasculature children’s vision artificial intelligence retinal development |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1101768/full |
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