Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China
BackgroundAsymptomatic transmission is a major concern for SARS-CoV-2 community spread; however, little information is available on demographic, virological characteristics and prognosis of asymptomatic cases.MethodsAll COVID-19 patients hospitalized in Guangdong Province from September 1, 2020 to F...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.830942/full |
| _version_ | 1818333559097655296 |
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| author | Hui Xu Cheng-yuan Xie Cheng-yuan Xie Pei-hong Li Pei-hong Li Zhong-liang Ji Zhong-liang Ji Jiu-feng Sun Bei Hu Xin Li Ming Fang Ming Fang Ming Fang |
| author_facet | Hui Xu Cheng-yuan Xie Cheng-yuan Xie Pei-hong Li Pei-hong Li Zhong-liang Ji Zhong-liang Ji Jiu-feng Sun Bei Hu Xin Li Ming Fang Ming Fang Ming Fang |
| author_sort | Hui Xu |
| collection | DOAJ |
| description | BackgroundAsymptomatic transmission is a major concern for SARS-CoV-2 community spread; however, little information is available on demographic, virological characteristics and prognosis of asymptomatic cases.MethodsAll COVID-19 patients hospitalized in Guangdong Province from September 1, 2020 to February 28, 2021, were included and were divided into asymptomatic and symptomaticgroup. The source country of all patients, clinical laboratory test results, the genotype of virus and the time of SARS-CoV-2 RNA turning negative or hospitalization were confirmed.ResultsTotal 233 patients from 57 different countries or regions were included, with 83 (35.6%) asymptomatic and 150 (64.4%) symptomatic patients. Asymptomatic cases were younger (P = 0.019), lower rate in comorbidities (P = 0.021) such as hypertension (P = 0.083) and chronic liver disease (P = 0.045), lower PCT (P = 0.021), DDI (P < 0.001) and ALT (P = 0.029), but higher WBC count (P = 0.002) and lymphocyte (P = 0.011) than symptomatic patients. As for SARS-CoV-2 subtypes, patients infected with B.1.1 (53.8%), B.1.351 (81.8%) and B.1.524 (60%) are mainly asymptomatic, while infected with B, B.1, B.1.1.63, B.1.1.7, B.1.36, B.1.36.1, B.1.36.16, B.1.5 and B.6 were inclined to be symptomatic. Patients infected with variant B.1.351 and B.1.524 spent longer time in SARS-CoV-2 RNA turn negative (26 days, P = 0.085; 41 days, P = 0.007) and hospitalization (28 days, P = 0.085; 43 days, P = 0.004).ConclusionsThe asymptomatic cases are prone to develop in patients with younger age, less comorbidities andinfected with B.1.1 and B.1.524 variants. More attention should be paid for lineage B.1.524 because it can significantly prolong the SARS-CoV-2 RNA negative conversion time and hospitalization in infected cases. |
| first_indexed | 2024-12-13T13:53:33Z |
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| id | doaj.art-e47cff071ce442c8b12150ffcdd3a85c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T13:53:33Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e47cff071ce442c8b12150ffcdd3a85c2022-12-21T23:43:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01910.3389/fmed.2022.830942830942Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South ChinaHui Xu0Cheng-yuan Xie1Cheng-yuan Xie2Pei-hong Li3Pei-hong Li4Zhong-liang Ji5Zhong-liang Ji6Jiu-feng Sun7Bei Hu8Xin Li9Ming Fang10Ming Fang11Ming Fang12Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaShantou University Medical College, Shantou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Emergency, Shenzhen University General Hospital, Shenzhen, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaShantou University Medical College, Shantou, ChinaBackgroundAsymptomatic transmission is a major concern for SARS-CoV-2 community spread; however, little information is available on demographic, virological characteristics and prognosis of asymptomatic cases.MethodsAll COVID-19 patients hospitalized in Guangdong Province from September 1, 2020 to February 28, 2021, were included and were divided into asymptomatic and symptomaticgroup. The source country of all patients, clinical laboratory test results, the genotype of virus and the time of SARS-CoV-2 RNA turning negative or hospitalization were confirmed.ResultsTotal 233 patients from 57 different countries or regions were included, with 83 (35.6%) asymptomatic and 150 (64.4%) symptomatic patients. Asymptomatic cases were younger (P = 0.019), lower rate in comorbidities (P = 0.021) such as hypertension (P = 0.083) and chronic liver disease (P = 0.045), lower PCT (P = 0.021), DDI (P < 0.001) and ALT (P = 0.029), but higher WBC count (P = 0.002) and lymphocyte (P = 0.011) than symptomatic patients. As for SARS-CoV-2 subtypes, patients infected with B.1.1 (53.8%), B.1.351 (81.8%) and B.1.524 (60%) are mainly asymptomatic, while infected with B, B.1, B.1.1.63, B.1.1.7, B.1.36, B.1.36.1, B.1.36.16, B.1.5 and B.6 were inclined to be symptomatic. Patients infected with variant B.1.351 and B.1.524 spent longer time in SARS-CoV-2 RNA turn negative (26 days, P = 0.085; 41 days, P = 0.007) and hospitalization (28 days, P = 0.085; 43 days, P = 0.004).ConclusionsThe asymptomatic cases are prone to develop in patients with younger age, less comorbidities andinfected with B.1.1 and B.1.524 variants. More attention should be paid for lineage B.1.524 because it can significantly prolong the SARS-CoV-2 RNA negative conversion time and hospitalization in infected cases.https://www.frontiersin.org/articles/10.3389/fmed.2022.830942/fullCOVID-19asymptomatic patientsvariantsprognosisepidemiology |
| spellingShingle | Hui Xu Cheng-yuan Xie Cheng-yuan Xie Pei-hong Li Pei-hong Li Zhong-liang Ji Zhong-liang Ji Jiu-feng Sun Bei Hu Xin Li Ming Fang Ming Fang Ming Fang Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China Frontiers in Medicine COVID-19 asymptomatic patients variants prognosis epidemiology |
| title | Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China |
| title_full | Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China |
| title_fullStr | Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China |
| title_full_unstemmed | Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China |
| title_short | Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South China |
| title_sort | demographic virological characteristics and prognosis of asymptomatic covid 19 patients in south china |
| topic | COVID-19 asymptomatic patients variants prognosis epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.830942/full |
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