Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study
Background and purpose: Beta thalassemia major is one of the most common inherited blood diseases and patients with this condition require regular blood transfusions. The resulting iron overload deposition causes endocrine gland disorders, including growth hormone (GH) abnormality. In this study, we...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Mazandaran University of Medical Sciences
2020-05-01
|
Series: | Journal of Mazandaran University of Medical Sciences |
Subjects: | |
Online Access: | http://jmums.mazums.ac.ir/article-1-15148-en.html |
_version_ | 1797944104985821184 |
---|---|
author | Ahmad Tamaddoni Morteza Alijanpour |
author_facet | Ahmad Tamaddoni Morteza Alijanpour |
author_sort | Ahmad Tamaddoni |
collection | DOAJ |
description | Background and purpose: Beta thalassemia major is one of the most common inherited blood diseases and patients with this condition require regular blood transfusions. The resulting iron overload deposition causes endocrine gland disorders, including growth hormone (GH) abnormality. In this study, we examined the effects of recombinant growth hormone (rGH) in these patients.
Materials and methods: This retrospective study was performed in thalassemia major patients in Amirkola Thalassemia Center, using the medical records (2011-2018), to evaluate the therapeutic effects of rGH on growth velocity of six short stature patients aged 7-15 years (four boys and two girls). On the basis of abnormal or normal response to GH provocation test, the patients were included in GH deficiency (GHD) group (n=3) and idiopathic short stature (ISS) group (n=3), respectively. The data were analyzed in SPSS-18.
Results: The mean age of patients was 11.00 ± 2.75 years old. The mean values for growth velocity before and after the treatment were 4.00± 0.86 and 7.83 ± 1.25 cm/year in GHD group (P=0.057) and 4.06 ± 0.81 and 6.00 ± 1.50 cm/year in ISS group, respectively (P=0.023).
Conclusion: In this study, the positive therapeutic effects of rGh in improvement of growth velocity were seen in thalassemia major patients (both GHD and ISS groups). |
first_indexed | 2024-04-10T20:34:24Z |
format | Article |
id | doaj.art-e47dc6d16c84409686ee7069281a61f0 |
institution | Directory Open Access Journal |
issn | 1735-9260 1735-9279 |
language | English |
last_indexed | 2024-04-10T20:34:24Z |
publishDate | 2020-05-01 |
publisher | Mazandaran University of Medical Sciences |
record_format | Article |
series | Journal of Mazandaran University of Medical Sciences |
spelling | doaj.art-e47dc6d16c84409686ee7069281a61f02023-01-25T05:01:54ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-05-01301855160Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective StudyAhmad Tamaddoni0Morteza Alijanpour1 Associate Professor, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Assistant Professor, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Background and purpose: Beta thalassemia major is one of the most common inherited blood diseases and patients with this condition require regular blood transfusions. The resulting iron overload deposition causes endocrine gland disorders, including growth hormone (GH) abnormality. In this study, we examined the effects of recombinant growth hormone (rGH) in these patients. Materials and methods: This retrospective study was performed in thalassemia major patients in Amirkola Thalassemia Center, using the medical records (2011-2018), to evaluate the therapeutic effects of rGH on growth velocity of six short stature patients aged 7-15 years (four boys and two girls). On the basis of abnormal or normal response to GH provocation test, the patients were included in GH deficiency (GHD) group (n=3) and idiopathic short stature (ISS) group (n=3), respectively. The data were analyzed in SPSS-18. Results: The mean age of patients was 11.00 ± 2.75 years old. The mean values for growth velocity before and after the treatment were 4.00± 0.86 and 7.83 ± 1.25 cm/year in GHD group (P=0.057) and 4.06 ± 0.81 and 6.00 ± 1.50 cm/year in ISS group, respectively (P=0.023). Conclusion: In this study, the positive therapeutic effects of rGh in improvement of growth velocity were seen in thalassemia major patients (both GHD and ISS groups).http://jmums.mazums.ac.ir/article-1-15148-en.htmlmajor thalassemiaendocrine glandsshort staturerecombinant growth hormone |
spellingShingle | Ahmad Tamaddoni Morteza Alijanpour Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study Journal of Mazandaran University of Medical Sciences major thalassemia endocrine glands short stature recombinant growth hormone |
title | Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients:
A Retrospective Study |
title_full | Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients:
A Retrospective Study |
title_fullStr | Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients:
A Retrospective Study |
title_full_unstemmed | Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients:
A Retrospective Study |
title_short | Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients:
A Retrospective Study |
title_sort | therapeutic effects of recombinant growth hormone in improving the growth of thalassemia major patients a retrospective study |
topic | major thalassemia endocrine glands short stature recombinant growth hormone |
url | http://jmums.mazums.ac.ir/article-1-15148-en.html |
work_keys_str_mv | AT ahmadtamaddoni therapeuticeffectsofrecombinantgrowthhormoneinimprovingthegrowthofthalassemiamajorpatientsaretrospectivestudy AT mortezaalijanpour therapeuticeffectsofrecombinantgrowthhormoneinimprovingthegrowthofthalassemiamajorpatientsaretrospectivestudy |