Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (<i>HPV</i>) infection, particularly <i>HPV-16</i>, may also sig...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/12/779 |
| _version_ | 1797460772966629376 |
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| author | Joanna Sobocińska Joanna Nowakowska Sara Molenda Anna Olechnowicz Kacper Guglas Joanna Kozłowska-Masłoń Urszula Kazimierczak Marta Machnik Urszula Oleksiewicz Anna Teresiak Katarzyna Lamperska Tomasz Kolenda |
| author_facet | Joanna Sobocińska Joanna Nowakowska Sara Molenda Anna Olechnowicz Kacper Guglas Joanna Kozłowska-Masłoń Urszula Kazimierczak Marta Machnik Urszula Oleksiewicz Anna Teresiak Katarzyna Lamperska Tomasz Kolenda |
| author_sort | Joanna Sobocińska |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (<i>HPV</i>) infection, particularly <i>HPV-16</i>, may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, <i>ZFP28</i>, <i>ZNF132</i>, <i>ZNF418</i>, <i>ZNF426</i>, <i>ZNF540</i>, and <i>ZNF880</i>, were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between <i>HPV</i>-positive vs. <i>HPV</i>-negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of <i>ZNF418</i> and <i>ZNF540</i> showed better survival rates than those with a lower expression. In addition, the level of <i>ZNF540</i> expression in <i>HPV</i>-positive (<i>HPV(+)</i>) patients was higher than in <i>HPV</i>-negative (<i>HPV(−)</i>) patients (<i>p</i> < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that <i>ZNF540</i> expression highly correlates with <i>HPV</i> infection, which renders <i>ZNF540</i> a potential biomarker for HNSCC prognosis and treatment. |
| first_indexed | 2024-03-09T17:09:49Z |
| format | Article |
| id | doaj.art-e47e4bfac8e04bdd835fc56364220d31 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T17:09:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-e47e4bfac8e04bdd835fc56364220d312023-11-24T14:13:26ZengMDPI AGCurrent Oncology1198-00521718-77292022-12-0129129896991510.3390/curroncol29120779Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a BiomarkerJoanna Sobocińska0Joanna Nowakowska1Sara Molenda2Anna Olechnowicz3Kacper Guglas4Joanna Kozłowska-Masłoń5Urszula Kazimierczak6Marta Machnik7Urszula Oleksiewicz8Anna Teresiak9Katarzyna Lamperska10Tomasz Kolenda11Laboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandLaboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandLaboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, PolandLaboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandLaboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandLaboratory of Cancer Genetics, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, PolandHead and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (<i>HPV</i>) infection, particularly <i>HPV-16</i>, may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, <i>ZFP28</i>, <i>ZNF132</i>, <i>ZNF418</i>, <i>ZNF426</i>, <i>ZNF540</i>, and <i>ZNF880</i>, were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between <i>HPV</i>-positive vs. <i>HPV</i>-negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of <i>ZNF418</i> and <i>ZNF540</i> showed better survival rates than those with a lower expression. In addition, the level of <i>ZNF540</i> expression in <i>HPV</i>-positive (<i>HPV(+)</i>) patients was higher than in <i>HPV</i>-negative (<i>HPV(−)</i>) patients (<i>p</i> < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that <i>ZNF540</i> expression highly correlates with <i>HPV</i> infection, which renders <i>ZNF540</i> a potential biomarker for HNSCC prognosis and treatment.https://www.mdpi.com/1718-7729/29/12/779HNSCC<i>HPV</i>KRAB-ZNFZNFbiomarkersTCGA |
| spellingShingle | Joanna Sobocińska Joanna Nowakowska Sara Molenda Anna Olechnowicz Kacper Guglas Joanna Kozłowska-Masłoń Urszula Kazimierczak Marta Machnik Urszula Oleksiewicz Anna Teresiak Katarzyna Lamperska Tomasz Kolenda Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker Current Oncology HNSCC <i>HPV</i> KRAB-ZNF ZNF biomarkers TCGA |
| title | Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker |
| title_full | Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker |
| title_fullStr | Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker |
| title_full_unstemmed | Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker |
| title_short | Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker |
| title_sort | zinc finger proteins in head and neck squamous cell carcinomas znf540 may serve as a biomarker |
| topic | HNSCC <i>HPV</i> KRAB-ZNF ZNF biomarkers TCGA |
| url | https://www.mdpi.com/1718-7729/29/12/779 |
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