Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study
Abstract Aims/Introduction The mechanisms underlying hypertriglyceridemia‐induced impaired glucose tolerance in Japanese individuals remain unclear. We aimed to evaluate the effect of hypertriglyceridemia on glucose metabolism in comparison with that of increased low‐density lipoprotein or decreased...
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.13398 |
| _version_ | 1819298911251070976 |
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| author | Yukiko Nonoyama Mayumi Yamamoto Shino Oba Yukio Horikawa Chisato Nagata Daisuke Yabe Jun Takeda Gifu Diabetes Study Group |
| author_facet | Yukiko Nonoyama Mayumi Yamamoto Shino Oba Yukio Horikawa Chisato Nagata Daisuke Yabe Jun Takeda Gifu Diabetes Study Group |
| author_sort | Yukiko Nonoyama |
| collection | DOAJ |
| description | Abstract Aims/Introduction The mechanisms underlying hypertriglyceridemia‐induced impaired glucose tolerance in Japanese individuals remain unclear. We aimed to evaluate the effect of hypertriglyceridemia on glucose metabolism in comparison with that of increased low‐density lipoprotein or decreased high‐density lipoprotein levels and to elucidate the sex differences in hypertriglyceridemia‐related dietary intake among Japanese individuals. Materials and Methods We randomly selected 898 (384 men and 514 women) participants aged 40–78 years in the Gifu Diabetes Study; those taking medication for dyslipidemia or diabetes mellitus were excluded. Serum levels of glucose metabolism parameters and the food frequency were measured cross‐sectionally. The glycated hemoglobin was measured again after 5 years. Results Glucose metabolism parameters and the percentage of individuals with impaired glucose tolerance were significantly higher in the high triglyceride group in men and women. Similar trends were observed in the low high‐density lipoprotein group, but only in men. Meanwhile, only the homeostasis model assessment of insulin resistance was higher in the high low‐density lipoprotein group. In non‐obese men, the percentage of energy intake from alcohol per total daily energy intake was significantly greater in the high triglyceride group. In obese women, the total energy intake was significantly greater in the high triglyceride group. At the 5‐year follow up, the risk of elevated glycated hemoglobin levels with hypertriglyceridemia was increased in men. Conclusions Hypertriglyceridemia is a stronger risk factor for impaired glucose tolerance than increased low‐density lipoprotein or decreased high‐density lipoprotein. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia. |
| first_indexed | 2024-12-24T05:37:25Z |
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| id | doaj.art-e47edc58b29945be8c7f075b3a4f456e |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-24T05:37:25Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-e47edc58b29945be8c7f075b3a4f456e2022-12-21T17:12:58ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-05-0112577178010.1111/jdi.13398Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes StudyYukiko Nonoyama0Mayumi Yamamoto1Shino Oba2Yukio Horikawa3Chisato Nagata4Daisuke Yabe5Jun Takeda6Gifu Diabetes Study GroupDepartment of Endocrinology and Metabolism Gifu University Graduate School of Medicine Gifu JapanHealth Administration Center and United Graduate School of Drug Discovery and Medical Information Sciences Gifu University Gifu JapanGraduate School of Health Sciences Gunma University Maebashi JapanDepartment of Endocrinology and Metabolism Gifu University Graduate School of Medicine Gifu JapanDepartment of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu JapanDepartment of Endocrinology and Metabolism Gifu University Graduate School of Medicine Gifu JapanTakeda hospital Kyoto JapanAbstract Aims/Introduction The mechanisms underlying hypertriglyceridemia‐induced impaired glucose tolerance in Japanese individuals remain unclear. We aimed to evaluate the effect of hypertriglyceridemia on glucose metabolism in comparison with that of increased low‐density lipoprotein or decreased high‐density lipoprotein levels and to elucidate the sex differences in hypertriglyceridemia‐related dietary intake among Japanese individuals. Materials and Methods We randomly selected 898 (384 men and 514 women) participants aged 40–78 years in the Gifu Diabetes Study; those taking medication for dyslipidemia or diabetes mellitus were excluded. Serum levels of glucose metabolism parameters and the food frequency were measured cross‐sectionally. The glycated hemoglobin was measured again after 5 years. Results Glucose metabolism parameters and the percentage of individuals with impaired glucose tolerance were significantly higher in the high triglyceride group in men and women. Similar trends were observed in the low high‐density lipoprotein group, but only in men. Meanwhile, only the homeostasis model assessment of insulin resistance was higher in the high low‐density lipoprotein group. In non‐obese men, the percentage of energy intake from alcohol per total daily energy intake was significantly greater in the high triglyceride group. In obese women, the total energy intake was significantly greater in the high triglyceride group. At the 5‐year follow up, the risk of elevated glycated hemoglobin levels with hypertriglyceridemia was increased in men. Conclusions Hypertriglyceridemia is a stronger risk factor for impaired glucose tolerance than increased low‐density lipoprotein or decreased high‐density lipoprotein. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia.https://doi.org/10.1111/jdi.13398HypertriglyceridemiaImpaired glucose toleranceSex differences |
| spellingShingle | Yukiko Nonoyama Mayumi Yamamoto Shino Oba Yukio Horikawa Chisato Nagata Daisuke Yabe Jun Takeda Gifu Diabetes Study Group Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study Journal of Diabetes Investigation Hypertriglyceridemia Impaired glucose tolerance Sex differences |
| title | Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study |
| title_full | Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study |
| title_fullStr | Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study |
| title_full_unstemmed | Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study |
| title_short | Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study |
| title_sort | effect of hypertriglyceridemia in dyslipidemia induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the japanese population the gifu diabetes study |
| topic | Hypertriglyceridemia Impaired glucose tolerance Sex differences |
| url | https://doi.org/10.1111/jdi.13398 |
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