Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes
Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric comparison has been made yet. Fifteen patients who unde...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/1/121 |
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| author | Silvia Rampazzo Marco Ferrari Maria Alessandra Sotgiu Gabriella Piu Maria Giuliana Solinas Noemi Usai Antonio Bulla Pietro Luciano Serra Federica Grieco Andrea Montella Vittorio Mazzarello Corrado Rubino |
| author_facet | Silvia Rampazzo Marco Ferrari Maria Alessandra Sotgiu Gabriella Piu Maria Giuliana Solinas Noemi Usai Antonio Bulla Pietro Luciano Serra Federica Grieco Andrea Montella Vittorio Mazzarello Corrado Rubino |
| author_sort | Silvia Rampazzo |
| collection | DOAJ |
| description | Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric comparison has been made yet. Fifteen patients who underwent skin reconstruction with Integra<sup>®</sup> or Pelnac<sup>®</sup> were retrospectively evaluated. After at least 12 months of follow-up, an objective and quantitative assessment of several skin biophysical properties, such as color, texture, elasticity, hydration, glossiness and trans-epidermal water loss, were measured with non-invasive skin measurement devices. The grafted skin showed a reduction of the superficial hydration level and a tendency to lower values of trans-epidermal water loss with both dermal substitutes. Melanic and hemoglobin pigmentation were higher in comparison to the donor site in both groups, while a melanic pigmentation increase versus the surrounding skin was seen just with Integra<sup>®</sup>. Finally, the skin was found to be more elastic when reconstructed with Integra<sup>®</sup>. The skin barrier appeared to be intact in both groups. Hence, these substitutes are valuable means of skin regeneration. Integra<sup>®</sup> seems to be more advantageous for reconstructing areas that need more skin flexibility. |
| first_indexed | 2024-03-08T10:43:48Z |
| format | Article |
| id | doaj.art-e4803a3577b34a4db76d5889ebbdff66 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:43:48Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e4803a3577b34a4db76d5889ebbdff662024-01-26T17:21:08ZengMDPI AGLife2075-17292024-01-0114112110.3390/life14010121Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal SubstitutesSilvia Rampazzo0Marco Ferrari1Maria Alessandra Sotgiu2Gabriella Piu3Maria Giuliana Solinas4Noemi Usai5Antonio Bulla6Pietro Luciano Serra7Federica Grieco8Andrea Montella9Vittorio Mazzarello10Corrado Rubino11Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalySkinlab, Department of Biomedical Science, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Science, University of Sassari, 07100 Sassari, ItalySkinlab, Department of Biomedical Science, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Science, University of Sassari, 07100 Sassari, ItalyPlastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalyPlastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalyPlastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalyPlastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Science, University of Sassari, 07100 Sassari, ItalySkinlab, Department of Biomedical Science, University of Sassari, 07100 Sassari, ItalyPlastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, ItalySeveral dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric comparison has been made yet. Fifteen patients who underwent skin reconstruction with Integra<sup>®</sup> or Pelnac<sup>®</sup> were retrospectively evaluated. After at least 12 months of follow-up, an objective and quantitative assessment of several skin biophysical properties, such as color, texture, elasticity, hydration, glossiness and trans-epidermal water loss, were measured with non-invasive skin measurement devices. The grafted skin showed a reduction of the superficial hydration level and a tendency to lower values of trans-epidermal water loss with both dermal substitutes. Melanic and hemoglobin pigmentation were higher in comparison to the donor site in both groups, while a melanic pigmentation increase versus the surrounding skin was seen just with Integra<sup>®</sup>. Finally, the skin was found to be more elastic when reconstructed with Integra<sup>®</sup>. The skin barrier appeared to be intact in both groups. Hence, these substitutes are valuable means of skin regeneration. Integra<sup>®</sup> seems to be more advantageous for reconstructing areas that need more skin flexibility.https://www.mdpi.com/2075-1729/14/1/121dermal substitutesskin graftbiophysical propertiesregenerated skinIntegra<sup>®</sup>Pelnac<sup>®</sup> |
| spellingShingle | Silvia Rampazzo Marco Ferrari Maria Alessandra Sotgiu Gabriella Piu Maria Giuliana Solinas Noemi Usai Antonio Bulla Pietro Luciano Serra Federica Grieco Andrea Montella Vittorio Mazzarello Corrado Rubino Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes Life dermal substitutes skin graft biophysical properties regenerated skin Integra<sup>®</sup> Pelnac<sup>®</sup> |
| title | Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes |
| title_full | Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes |
| title_fullStr | Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes |
| title_full_unstemmed | Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes |
| title_short | Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes |
| title_sort | objective non invasive bio parametric evaluation of regenerated skin a comparison of two acellular dermal substitutes |
| topic | dermal substitutes skin graft biophysical properties regenerated skin Integra<sup>®</sup> Pelnac<sup>®</sup> |
| url | https://www.mdpi.com/2075-1729/14/1/121 |
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