Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

Broadly neutralizing antibodies (bnAbs) that neutralize diverse variants of a particular virus are of considerable therapeutic interest. Recent advances have enabled us to isolate and engineer these antibodies as therapeutics, but eliciting them through vaccination remains challenging, in part due t...

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Bibliographic Details
Main Authors:	Angela M Phillips, Daniel P Maurer, Caelan Brooks, Thomas Dupic, Aaron G Schmidt, Michael M Desai
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-01-01
Series:	eLife
Subjects:	antibody influenza epistasis evolution breadth
Online Access:	https://elifesciences.org/articles/83628

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