Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp.
ABSTRACT: In the search for an early biomarker of renal injury, this study aimed to determine the urinary protein profile of dogs with leishmaniasis without treatment and treated as determined by Brazilian legislation. The identification of proteinuria, its classification and the circumstances in wh...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Colégio Brasileiro de Patologia Animal (CBPA)
2021-11-01
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| Series: | Pesquisa Veterinária Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100421&tlng=en |
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| author | Pillar G. Valle Júlio C.C. Veado Vitor M. Ribeiro Pedro P.A. Teles Adriane P. Costa Val Lorraine R.S.M. Dornelas Leandro A. Fonseca Fabiola O. Paes Leme |
| author_facet | Pillar G. Valle Júlio C.C. Veado Vitor M. Ribeiro Pedro P.A. Teles Adriane P. Costa Val Lorraine R.S.M. Dornelas Leandro A. Fonseca Fabiola O. Paes Leme |
| author_sort | Pillar G. Valle |
| collection | DOAJ |
| description | ABSTRACT: In the search for an early biomarker of renal injury, this study aimed to determine the urinary protein profile of dogs with leishmaniasis without treatment and treated as determined by Brazilian legislation. The identification of proteinuria, its classification and the circumstances in which it takes place instigated this study. For this, 30 dogs from an outpatient clinic at a Veterinary Hospital in Belo Horizonte were evaluated. All animals underwent clinical and laboratory tests, which included renal biomarkers. The proteins were characterized using the SDS-page electrophoresis technique, and thus, a urinary protein profile was developed comparing patients considered clinically healthy with dogs infected with leishmaniasis that were under treatment and with untreated infected dogs. The results showed that the hematological and biochemical parameters showed similar behavior between the groups of healthy dogs and dogs with leishmaniasis treated, however a very heterogeneous pattern of urinary proteins can be observed and differed between healthy animals and animals with leishmaniasis, as well as between treated and untreated animals. The results suggest that the classification of proteinuria can be a tool that helps in the staging of animals infected with L. infantum and can differentiate them as to the severity of existing kidney injuries. |
| first_indexed | 2024-04-11T16:44:22Z |
| format | Article |
| id | doaj.art-e480bafd0d5d42a4991dad5f9ec52481 |
| institution | Directory Open Access Journal |
| issn | 1678-5150 |
| language | English |
| last_indexed | 2024-04-11T16:44:22Z |
| publishDate | 2021-11-01 |
| publisher | Colégio Brasileiro de Patologia Animal (CBPA) |
| record_format | Article |
| series | Pesquisa Veterinária Brasileira |
| spelling | doaj.art-e480bafd0d5d42a4991dad5f9ec524812022-12-22T04:13:36ZengColégio Brasileiro de Patologia Animal (CBPA)Pesquisa Veterinária Brasileira1678-51502021-11-014110.1590/1678-5150-pvb-6905Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp.Pillar G. Vallehttps://orcid.org/0000-0002-3736-6052Júlio C.C. VeadoVitor M. RibeiroPedro P.A. TelesAdriane P. Costa ValLorraine R.S.M. DornelasLeandro A. FonsecaFabiola O. Paes LemeABSTRACT: In the search for an early biomarker of renal injury, this study aimed to determine the urinary protein profile of dogs with leishmaniasis without treatment and treated as determined by Brazilian legislation. The identification of proteinuria, its classification and the circumstances in which it takes place instigated this study. For this, 30 dogs from an outpatient clinic at a Veterinary Hospital in Belo Horizonte were evaluated. All animals underwent clinical and laboratory tests, which included renal biomarkers. The proteins were characterized using the SDS-page electrophoresis technique, and thus, a urinary protein profile was developed comparing patients considered clinically healthy with dogs infected with leishmaniasis that were under treatment and with untreated infected dogs. The results showed that the hematological and biochemical parameters showed similar behavior between the groups of healthy dogs and dogs with leishmaniasis treated, however a very heterogeneous pattern of urinary proteins can be observed and differed between healthy animals and animals with leishmaniasis, as well as between treated and untreated animals. The results suggest that the classification of proteinuria can be a tool that helps in the staging of animals infected with L. infantum and can differentiate them as to the severity of existing kidney injuries.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100421&tlng=enLeishmania sp.dogskidneyproteinuriaelectrophoresisleishmaniasis |
| spellingShingle | Pillar G. Valle Júlio C.C. Veado Vitor M. Ribeiro Pedro P.A. Teles Adriane P. Costa Val Lorraine R.S.M. Dornelas Leandro A. Fonseca Fabiola O. Paes Leme Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. Pesquisa Veterinária Brasileira Leishmania sp. dogs kidney proteinuria electrophoresis leishmaniasis |
| title | Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. |
| title_full | Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. |
| title_fullStr | Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. |
| title_full_unstemmed | Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. |
| title_short | Characterization of proteinuria in treated and untreated dogs naturally infected with Leishmania sp. |
| title_sort | characterization of proteinuria in treated and untreated dogs naturally infected with leishmania sp |
| topic | Leishmania sp. dogs kidney proteinuria electrophoresis leishmaniasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100421&tlng=en |
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