Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer
Abstract. In recent years, the research of immune checkpoint inhibitors has made a great breakthrough in lung cancer treatment. Currently, a variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2020-10-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000001124 |
| _version_ | 1819051326477172736 |
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| author | Fang-Fei Qian Bao-Hui Han Pei-Fang Wei |
| author_facet | Fang-Fei Qian Bao-Hui Han Pei-Fang Wei |
| author_sort | Fang-Fei Qian |
| collection | DOAJ |
| description | Abstract. In recent years, the research of immune checkpoint inhibitors has made a great breakthrough in lung cancer treatment. Currently, a variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell death-ligand 1, and cytotoxic T-lymphocyte antigen 4, and so on. However, not all patients can benefit from the treatment. Abnormal antigen presentation, functional gene mutation, tumor microenvironment, and other factors can lead to primary or secondary resistance. In this paper, we reviewed the molecular mechanism of immune checkpoint inhibitor resistance and various combination strategies to overcome resistance, in order to expand the beneficial population and enable precision medicine. |
| first_indexed | 2024-12-21T12:02:10Z |
| format | Article |
| id | doaj.art-e481f26c686640ab80870236412e066f |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-21T12:02:10Z |
| publishDate | 2020-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-e481f26c686640ab80870236412e066f2022-12-21T19:04:48ZengWolters KluwerChinese Medical Journal0366-69992542-56412020-10-01133202444245510.1097/CM9.0000000000001124202010200-00010Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancerFang-Fei Qian0Bao-Hui Han1Pei-Fang Wei2Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.Abstract. In recent years, the research of immune checkpoint inhibitors has made a great breakthrough in lung cancer treatment. Currently, a variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell death-ligand 1, and cytotoxic T-lymphocyte antigen 4, and so on. However, not all patients can benefit from the treatment. Abnormal antigen presentation, functional gene mutation, tumor microenvironment, and other factors can lead to primary or secondary resistance. In this paper, we reviewed the molecular mechanism of immune checkpoint inhibitor resistance and various combination strategies to overcome resistance, in order to expand the beneficial population and enable precision medicine.http://journals.lww.com/10.1097/CM9.0000000000001124 |
| spellingShingle | Fang-Fei Qian Bao-Hui Han Pei-Fang Wei Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer Chinese Medical Journal |
| title | Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| title_full | Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| title_fullStr | Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| title_full_unstemmed | Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| title_short | Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| title_sort | mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer |
| url | http://journals.lww.com/10.1097/CM9.0000000000001124 |
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