Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
The fatty acid desaturase 1 (FADS1), also known as delta‐5 desaturase (D5D), is one of the rate‐limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long‐chain PUFAs (LC‐PUFAs). Reduced function of D5D and decreased hepatic FADS1 exp...
Main Authors: | Shaminie Athinarayanan, Yang‐Yi Fan, Xiaokun Wang, Evelyn Callaway, Defeng Cai, Naga Chalasani, Robert S. Chapkin, Wanqing Liu |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Health/LWW
2021-03-01
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Series: | Hepatology Communications |
Online Access: | https://doi.org/10.1002/hep4.1629 |
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