Exosomal Cargo in Ovarian Cancer Dissemination
Ovarian cancer (OC) has the highest mortality rate among all gynecologic cancers and is characterized by early peritoneal spread. The growth and development of OC are associated with the formation of ascitic fluid, creating a unique tumor microenvironment. Understanding the mechanisms of tumor progr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/12/615 |
| _version_ | 1827575300954783744 |
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| author | Ekaterina Dzhugashvili Svetlana Tamkovich |
| author_facet | Ekaterina Dzhugashvili Svetlana Tamkovich |
| author_sort | Ekaterina Dzhugashvili |
| collection | DOAJ |
| description | Ovarian cancer (OC) has the highest mortality rate among all gynecologic cancers and is characterized by early peritoneal spread. The growth and development of OC are associated with the formation of ascitic fluid, creating a unique tumor microenvironment. Understanding the mechanisms of tumor progression is crucial in identifying new diagnostic biomarkers and developing novel therapeutic strategies. Exosomes, lipid bilayer vesicles measuring 30–150 nm in size, are known to establish a crucial link between malignant cells and their microenvironment. Additionally, the confirmed involvement of exosomes in carcinogenesis enables them to mediate the invasion, migration, metastasis, and angiogenesis of tumor cells. Functionally active non-coding RNAs (such as microRNAs, long non-coding RNAs, circRNAs), proteins, and lipid rafts transported within exosomes can activate numerous signaling pathways and modify gene expression. This review aims to expand our understanding of the role of exosomes and their contents in OC carcinogenesis processes such as epithelial-mesenchymal transition (EMT), angiogenesis, vasculogenic mimicry, tumor cell proliferation, and peritoneal spread. It also discusses the potential for utilizing exosomal cargo to develop novel “liquid biopsy” biomarkers for early OC diagnosis. |
| first_indexed | 2024-03-08T20:54:12Z |
| format | Article |
| id | doaj.art-e4839ee768f7420aaddd269909759697 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-08T20:54:12Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-e4839ee768f7420aaddd2699097596972023-12-22T14:00:41ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-12-0145129851986710.3390/cimb45120615Exosomal Cargo in Ovarian Cancer DisseminationEkaterina Dzhugashvili0Svetlana Tamkovich1V. Zelman Institute for Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, RussiaV. Zelman Institute for Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, RussiaOvarian cancer (OC) has the highest mortality rate among all gynecologic cancers and is characterized by early peritoneal spread. The growth and development of OC are associated with the formation of ascitic fluid, creating a unique tumor microenvironment. Understanding the mechanisms of tumor progression is crucial in identifying new diagnostic biomarkers and developing novel therapeutic strategies. Exosomes, lipid bilayer vesicles measuring 30–150 nm in size, are known to establish a crucial link between malignant cells and their microenvironment. Additionally, the confirmed involvement of exosomes in carcinogenesis enables them to mediate the invasion, migration, metastasis, and angiogenesis of tumor cells. Functionally active non-coding RNAs (such as microRNAs, long non-coding RNAs, circRNAs), proteins, and lipid rafts transported within exosomes can activate numerous signaling pathways and modify gene expression. This review aims to expand our understanding of the role of exosomes and their contents in OC carcinogenesis processes such as epithelial-mesenchymal transition (EMT), angiogenesis, vasculogenic mimicry, tumor cell proliferation, and peritoneal spread. It also discusses the potential for utilizing exosomal cargo to develop novel “liquid biopsy” biomarkers for early OC diagnosis.https://www.mdpi.com/1467-3045/45/12/615exosomesexosomal cargomicroRNAproteinsliquid biopsyovarian cancer |
| spellingShingle | Ekaterina Dzhugashvili Svetlana Tamkovich Exosomal Cargo in Ovarian Cancer Dissemination Current Issues in Molecular Biology exosomes exosomal cargo microRNA proteins liquid biopsy ovarian cancer |
| title | Exosomal Cargo in Ovarian Cancer Dissemination |
| title_full | Exosomal Cargo in Ovarian Cancer Dissemination |
| title_fullStr | Exosomal Cargo in Ovarian Cancer Dissemination |
| title_full_unstemmed | Exosomal Cargo in Ovarian Cancer Dissemination |
| title_short | Exosomal Cargo in Ovarian Cancer Dissemination |
| title_sort | exosomal cargo in ovarian cancer dissemination |
| topic | exosomes exosomal cargo microRNA proteins liquid biopsy ovarian cancer |
| url | https://www.mdpi.com/1467-3045/45/12/615 |
| work_keys_str_mv | AT ekaterinadzhugashvili exosomalcargoinovariancancerdissemination AT svetlanatamkovich exosomalcargoinovariancancerdissemination |