Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation

Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation

Objectives This study aimed to evaluate the potential mitigating effect of fisetin on monosodium glutamate (MSG)-induced testicular toxicity and investigate the possible involvement of silent mating type information regulation 2 homolog 1 (SIRT1) in this effect.Methods Forty male rats were divided i...

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Bibliographic Details
Main Authors: Fatma H. Rizk, Nema A. Soliman, Suzan E. Abo-Elnasr, Heba A. Mahmoud, Muhammad T. Abdel Ghafar, Rasha A. Elkholy, Ola A. ELshora, Reham A. Mariah, Shaimaa Samir Amin Mashal, Amira A. El Saadany
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Redox Report
Subjects:
Monosodium glutamate
oxidative stress
fisetin
testicular toxicity
SIRT1
NOX4
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2022.2116551

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