Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug. This study aimed to address the toxic effects of CP on male fertility and the possible ameliorative role of hesperidin (HSP). Thirty-two adult albino rats were randomly divided into four groups, namely, the n...

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Bibliographic Details
Main Authors: Tarek Khamis, Abdelmonem Awad Hegazy, Samaa Salah Abd El-Fatah, Eman Ramadan Abdelfattah, Marwa Mohamed Mahmoud Abdelfattah, Liana Mihaela Fericean, Ahmed Hamed Arisha
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
cyclophosphamide
hesperidin
apoptosis
P53
iNOS
oxidative stress
Online Access:https://www.mdpi.com/1424-8247/16/2/301

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