Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
Abstract Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce adverse prognosis, such as metastasis. In recent years, the progress of research on...
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| Format: | Article |
| Language: | English |
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Wiley
2018-09-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s40169-018-0205-6 |
| _version_ | 1811327906589179904 |
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| author | Weilong Chen Yuanyuan Qin Suling Liu |
| author_facet | Weilong Chen Yuanyuan Qin Suling Liu |
| author_sort | Weilong Chen |
| collection | DOAJ |
| description | Abstract Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce adverse prognosis, such as metastasis. In recent years, the progress of research on cytokine-modulated tumor microenvironment and breast cancer stem cells (BCSCs) has shed light on defining the mechanisms of drug resistance gradually. In this review, we have discussed cytokine regulation on breast cancer chemoresistance. Cytokines can affect tumor cell behavior or reprogram tumor niche through specific signaling pathways, thereby regulating the progress of drug resistance. In addition, we summarized the mutually regulatory networks between cytokines and BCSCs in mediating chemoresistance. Cytokines in the tumor microenvironment can regulate the self-renewal and survival of BCSCs in a variety of ways, sequentially promoting chemotherapeutic resistance. Therefore, the combinational treatment of BCSC targeting and cytokine blockade may have a positive effect on the clinical treatment of breast cancer. |
| first_indexed | 2024-04-13T15:16:16Z |
| format | Article |
| id | doaj.art-e489e638cda34473a5e796e5171fa304 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-04-13T15:16:16Z |
| publishDate | 2018-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-e489e638cda34473a5e796e5171fa3042022-12-22T02:41:52ZengWileyClinical and Translational Medicine2001-13262018-09-017111310.1186/s40169-018-0205-6Cytokines, breast cancer stem cells (BCSCs) and chemoresistanceWeilong Chen0Yuanyuan Qin1Suling Liu2School of Life Science, The CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science & Technology of ChinaSchool of Life Science, The CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science & Technology of ChinaFudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Key Laboratory of Medical Epigenetics and Metabolism; Innovation Center for Cell Signaling Network, Shanghai Medical College; Fudan UniversityAbstract Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce adverse prognosis, such as metastasis. In recent years, the progress of research on cytokine-modulated tumor microenvironment and breast cancer stem cells (BCSCs) has shed light on defining the mechanisms of drug resistance gradually. In this review, we have discussed cytokine regulation on breast cancer chemoresistance. Cytokines can affect tumor cell behavior or reprogram tumor niche through specific signaling pathways, thereby regulating the progress of drug resistance. In addition, we summarized the mutually regulatory networks between cytokines and BCSCs in mediating chemoresistance. Cytokines in the tumor microenvironment can regulate the self-renewal and survival of BCSCs in a variety of ways, sequentially promoting chemotherapeutic resistance. Therefore, the combinational treatment of BCSC targeting and cytokine blockade may have a positive effect on the clinical treatment of breast cancer.http://link.springer.com/article/10.1186/s40169-018-0205-6Breast cancer stem cells (BCSCs)CytokineChemoresistanceTumor microenvironment |
| spellingShingle | Weilong Chen Yuanyuan Qin Suling Liu Cytokines, breast cancer stem cells (BCSCs) and chemoresistance Clinical and Translational Medicine Breast cancer stem cells (BCSCs) Cytokine Chemoresistance Tumor microenvironment |
| title | Cytokines, breast cancer stem cells (BCSCs) and chemoresistance |
| title_full | Cytokines, breast cancer stem cells (BCSCs) and chemoresistance |
| title_fullStr | Cytokines, breast cancer stem cells (BCSCs) and chemoresistance |
| title_full_unstemmed | Cytokines, breast cancer stem cells (BCSCs) and chemoresistance |
| title_short | Cytokines, breast cancer stem cells (BCSCs) and chemoresistance |
| title_sort | cytokines breast cancer stem cells bcscs and chemoresistance |
| topic | Breast cancer stem cells (BCSCs) Cytokine Chemoresistance Tumor microenvironment |
| url | http://link.springer.com/article/10.1186/s40169-018-0205-6 |
| work_keys_str_mv | AT weilongchen cytokinesbreastcancerstemcellsbcscsandchemoresistance AT yuanyuanqin cytokinesbreastcancerstemcellsbcscsandchemoresistance AT sulingliu cytokinesbreastcancerstemcellsbcscsandchemoresistance |