Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals
Transcription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/18/2/246 |
| _version_ | 1811280324604198912 |
|---|---|
| author | Seika Takayanagi-Kiya Taketoshi Kiya Takekazu Kunieda Takeo Kubo |
| author_facet | Seika Takayanagi-Kiya Taketoshi Kiya Takekazu Kunieda Takeo Kubo |
| author_sort | Seika Takayanagi-Kiya |
| collection | DOAJ |
| description | Transcription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and then provides an overview of the studies of Mblk-1 and their homologs. Mblk-1 family proteins are found broadly in animals and are shown to affect transcription activities. Studies have revealed that the mammalian homologs can interact with several cofactors and together regulate transcription. Interestingly, a recent study using the mouse homologs, Mlr1 and Mlr2, showed that one of their cofactor proteins, NOL4, have several splice variants with different effects on the transactivation activities of Mlr proteins. These findings suggest that there is an additional layer of the regulation of Mblk-1 family proteins by cofactor splice variants and provide novel insights into our current understanding of the roles of the conserved transcription factor family. |
| first_indexed | 2024-04-13T01:12:41Z |
| format | Article |
| id | doaj.art-e48eaf4948d04874aa9812a55f320529 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T01:12:41Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e48eaf4948d04874aa9812a55f3205292022-12-22T03:09:07ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-01-0118224610.3390/ijms18020246ijms18020246Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in MammalsSeika Takayanagi-Kiya0Taketoshi Kiya1Takekazu Kunieda2Takeo Kubo3Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920 1192, JapanDivision of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920 1192, JapanDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113 0033, JapanDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113 0033, JapanTranscription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and then provides an overview of the studies of Mblk-1 and their homologs. Mblk-1 family proteins are found broadly in animals and are shown to affect transcription activities. Studies have revealed that the mammalian homologs can interact with several cofactors and together regulate transcription. Interestingly, a recent study using the mouse homologs, Mlr1 and Mlr2, showed that one of their cofactor proteins, NOL4, have several splice variants with different effects on the transactivation activities of Mlr proteins. These findings suggest that there is an additional layer of the regulation of Mblk-1 family proteins by cofactor splice variants and provide novel insights into our current understanding of the roles of the conserved transcription factor family.http://www.mdpi.com/1422-0067/18/2/246honeybeetranscription factorMblk-1E93MBR-1Mlr1LCoRNOL4transcription cofactorsplice variants |
| spellingShingle | Seika Takayanagi-Kiya Taketoshi Kiya Takekazu Kunieda Takeo Kubo Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals International Journal of Molecular Sciences honeybee transcription factor Mblk-1 E93 MBR-1 Mlr1 LCoR NOL4 transcription cofactor splice variants |
| title | Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals |
| title_full | Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals |
| title_fullStr | Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals |
| title_full_unstemmed | Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals |
| title_short | Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals |
| title_sort | mblk 1 transcription factor family its roles in various animals and regulation by nol4 splice variants in mammals |
| topic | honeybee transcription factor Mblk-1 E93 MBR-1 Mlr1 LCoR NOL4 transcription cofactor splice variants |
| url | http://www.mdpi.com/1422-0067/18/2/246 |
| work_keys_str_mv | AT seikatakayanagikiya mblk1transcriptionfactorfamilyitsrolesinvariousanimalsandregulationbynol4splicevariantsinmammals AT taketoshikiya mblk1transcriptionfactorfamilyitsrolesinvariousanimalsandregulationbynol4splicevariantsinmammals AT takekazukunieda mblk1transcriptionfactorfamilyitsrolesinvariousanimalsandregulationbynol4splicevariantsinmammals AT takeokubo mblk1transcriptionfactorfamilyitsrolesinvariousanimalsandregulationbynol4splicevariantsinmammals |