Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the gro...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2009-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009 |
| _version_ | 1819061744356556800 |
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| author | Chen Zhong Yin Quanzhong Ma Genshan Zhang Hua Zheng Ruolong Wang Jiahong Gao Chunheng |
| author_facet | Chen Zhong Yin Quanzhong Ma Genshan Zhang Hua Zheng Ruolong Wang Jiahong Gao Chunheng |
| author_sort | Chen Zhong |
| collection | DOAJ |
| description | We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD. |
| first_indexed | 2024-12-21T14:47:45Z |
| format | Article |
| id | doaj.art-e4906ed6e0894fa7a62c0b887703a319 |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-21T14:47:45Z |
| publishDate | 2009-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-e4906ed6e0894fa7a62c0b887703a3192022-12-21T18:59:58ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852009-01-01322260263Myeloperoxidase gene-463G > a polymorphism and premature coronary artery diseaseChen ZhongYin QuanzhongMa GenshanZhang HuaZheng RuolongWang JiahongGao ChunhengWe investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009premature coronary artery diseasemyeloperoxidaseprotective genetic polymorphism |
| spellingShingle | Chen Zhong Yin Quanzhong Ma Genshan Zhang Hua Zheng Ruolong Wang Jiahong Gao Chunheng Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease Genetics and Molecular Biology premature coronary artery disease myeloperoxidase protective genetic polymorphism |
| title | Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease |
| title_full | Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease |
| title_fullStr | Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease |
| title_full_unstemmed | Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease |
| title_short | Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease |
| title_sort | myeloperoxidase gene 463g a polymorphism and premature coronary artery disease |
| topic | premature coronary artery disease myeloperoxidase protective genetic polymorphism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009 |
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