Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis
To describe and evaluate outcomes of Gamma Knife radiosurgery (GK) for the treatment of pituitary tumors over the past twenty years, a systematic review and meta-analysis according to PRISMA statement was performed. Articles counting more than 30 patients were included. A weighted random effects mod...
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4998 |
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| author | Luigi Albano Marco Losa Lina Raffaella Barzaghi Ajay Niranjan Zaid Siddiqui John C. Flickinger Lawrence Dade Lunsford Pietro Mortini |
| author_facet | Luigi Albano Marco Losa Lina Raffaella Barzaghi Ajay Niranjan Zaid Siddiqui John C. Flickinger Lawrence Dade Lunsford Pietro Mortini |
| author_sort | Luigi Albano |
| collection | DOAJ |
| description | To describe and evaluate outcomes of Gamma Knife radiosurgery (GK) for the treatment of pituitary tumors over the past twenty years, a systematic review and meta-analysis according to PRISMA statement was performed. Articles counting more than 30 patients were included. A weighted random effects models was used to calculate pooled outcome estimates. From 459 abstract reviews, 52 retrospective studies were included. Among them, 18 reported on non-functioning pituitary adenomas (NFPA), 13 on growth hormone (GH)-secreting adenomas, six on adrenocorticotropic hormone (ACTH)-secreting adenomas, four on prolactin hormone (PRL)-secreting adenomas, and 11 on craniopharyngiomas. Overall tumor control and five-year progression free survival (PFS) estimate after one GK procedure for NFPA was 93% (95% CI 89–97%) and 95% (95% CI 91–99%), respectively. In case of secreting pituitary adenomas, overall remission (cure without need for medication) estimates were 45% (95% CI 35–54%) for GH-secreting adenomas, 64% (95% CI 0.52–0.75%) for ACTH-secreting adenomas and 34% (95% CI: 19–48%) for PRL-secreting adenomas. The pooled analysis for overall tumor control and five-year PFS estimate after GK for craniopharyngioma was 74% (95% CI 67–81%) and 70% (95% CI: 64–76%), respectively. This meta-analysis confirms and quantifies safety and effectiveness of GK for pituitary tumors. |
| first_indexed | 2024-03-10T07:05:16Z |
| format | Article |
| id | doaj.art-e490f7cc1b9f4488a08abc8d8d8763d9 |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:05:16Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e490f7cc1b9f4488a08abc8d8d8763d92023-11-22T15:55:29ZengMDPI AGCancers2072-66942021-10-011319499810.3390/cancers13194998Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-AnalysisLuigi Albano0Marco Losa1Lina Raffaella Barzaghi2Ajay Niranjan3Zaid Siddiqui4John C. Flickinger5Lawrence Dade Lunsford6Pietro Mortini7Departments of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, ItalyDepartments of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, ItalyDepartments of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, ItalyDepartments of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USACenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USACenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USADepartments of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USADepartments of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, ItalyTo describe and evaluate outcomes of Gamma Knife radiosurgery (GK) for the treatment of pituitary tumors over the past twenty years, a systematic review and meta-analysis according to PRISMA statement was performed. Articles counting more than 30 patients were included. A weighted random effects models was used to calculate pooled outcome estimates. From 459 abstract reviews, 52 retrospective studies were included. Among them, 18 reported on non-functioning pituitary adenomas (NFPA), 13 on growth hormone (GH)-secreting adenomas, six on adrenocorticotropic hormone (ACTH)-secreting adenomas, four on prolactin hormone (PRL)-secreting adenomas, and 11 on craniopharyngiomas. Overall tumor control and five-year progression free survival (PFS) estimate after one GK procedure for NFPA was 93% (95% CI 89–97%) and 95% (95% CI 91–99%), respectively. In case of secreting pituitary adenomas, overall remission (cure without need for medication) estimates were 45% (95% CI 35–54%) for GH-secreting adenomas, 64% (95% CI 0.52–0.75%) for ACTH-secreting adenomas and 34% (95% CI: 19–48%) for PRL-secreting adenomas. The pooled analysis for overall tumor control and five-year PFS estimate after GK for craniopharyngioma was 74% (95% CI 67–81%) and 70% (95% CI: 64–76%), respectively. This meta-analysis confirms and quantifies safety and effectiveness of GK for pituitary tumors.https://www.mdpi.com/2072-6694/13/19/4998gamma kniferadiosurgerypituitarypituitary adenomapituitary tumorcraniopharyngioma |
| spellingShingle | Luigi Albano Marco Losa Lina Raffaella Barzaghi Ajay Niranjan Zaid Siddiqui John C. Flickinger Lawrence Dade Lunsford Pietro Mortini Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis Cancers gamma knife radiosurgery pituitary pituitary adenoma pituitary tumor craniopharyngioma |
| title | Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis |
| title_full | Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis |
| title_fullStr | Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis |
| title_short | Gamma Knife Radiosurgery for Pituitary Tumors: A Systematic Review and Meta-Analysis |
| title_sort | gamma knife radiosurgery for pituitary tumors a systematic review and meta analysis |
| topic | gamma knife radiosurgery pituitary pituitary adenoma pituitary tumor craniopharyngioma |
| url | https://www.mdpi.com/2072-6694/13/19/4998 |
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