A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/9/2160 |
| _version_ | 1797568779021975552 |
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| author | Guido Gambacorta David C. Apperley Ian R. Baxendale |
| author_facet | Guido Gambacorta David C. Apperley Ian R. Baxendale |
| author_sort | Guido Gambacorta |
| collection | DOAJ |
| description | The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation. |
| first_indexed | 2024-03-10T20:01:57Z |
| format | Article |
| id | doaj.art-e491b1a04643440c858fc2e580edfbfd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:01:57Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e491b1a04643440c858fc2e580edfbfd2023-11-19T23:32:04ZengMDPI AGMolecules1420-30492020-05-01259216010.3390/molecules25092160A One-Pot Divergent Sequence to Pyrazole and Quinoline DerivativesGuido Gambacorta0David C. Apperley1Ian R. Baxendale2Department of Chemistry, University of Durham, South Road Durham DH1 3LE, UKDepartment of Chemistry, University of Durham, South Road Durham DH1 3LE, UKDepartment of Chemistry, University of Durham, South Road Durham DH1 3LE, UKThe hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.https://www.mdpi.com/1420-3049/25/9/2160pyrazoleoxindoleisatinPfitzinger reactionKnorr pyrazole synthesisquinoline |
| spellingShingle | Guido Gambacorta David C. Apperley Ian R. Baxendale A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives Molecules pyrazole oxindole isatin Pfitzinger reaction Knorr pyrazole synthesis quinoline |
| title | A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives |
| title_full | A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives |
| title_fullStr | A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives |
| title_full_unstemmed | A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives |
| title_short | A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives |
| title_sort | one pot divergent sequence to pyrazole and quinoline derivatives |
| topic | pyrazole oxindole isatin Pfitzinger reaction Knorr pyrazole synthesis quinoline |
| url | https://www.mdpi.com/1420-3049/25/9/2160 |
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