Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy
The effects of Helicobacter pylori eradication on gastric mucosa-colonizing microbes in patients with functional dyspepsia (FD) remain unclear. Here, we explored microbial variation induced by H. pylori infection and eradication treatment in FD patients. Gastric microbial abundance and diversity wer...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1288920/full |
| _version_ | 1827387172701863936 |
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| author | Wenxue Wang Wenxue Wang Zhongjian Liu Yu Zhang Zhiping Guo Jieyu Liu Siyun Li Jihua Huang Jiawei Geng Jiawei Geng Jiawei Geng Fan Zhang Qiang Guo |
| author_facet | Wenxue Wang Wenxue Wang Zhongjian Liu Yu Zhang Zhiping Guo Jieyu Liu Siyun Li Jihua Huang Jiawei Geng Jiawei Geng Jiawei Geng Fan Zhang Qiang Guo |
| author_sort | Wenxue Wang |
| collection | DOAJ |
| description | The effects of Helicobacter pylori eradication on gastric mucosa-colonizing microbes in patients with functional dyspepsia (FD) remain unclear. Here, we explored microbial variation induced by H. pylori infection and eradication treatment in FD patients. Gastric microbial abundance and diversity were significantly reduced in the H. pylori-infected FD patients. Eradication treatment increased alpha and beta diversity of gastric mucosa-colonizing microbes, and promoted the expansion of several probiotic microbes, such as Leuconostoc mesenteroides, which exhibited a matched antagonistic performance against H. pylori. Significant variation was observed in gastric mucosa-colonizing microbes between H. pylori-positive and H. pylori-negative FD patients. Eradication treatment induced microbial diversity recovery and may provide sufficient nutrition and space for probiotic microbes, such as Leuconostoc mesenteroides. |
| first_indexed | 2024-03-08T15:57:03Z |
| format | Article |
| id | doaj.art-e497952eb34d4439917e9313cc1bb236 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T15:57:03Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e497952eb34d4439917e9313cc1bb2362024-01-08T19:18:09ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-11-011410.3389/fmicb.2023.12889201288920Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapyWenxue Wang0Wenxue Wang1Zhongjian Liu2Yu Zhang3Zhiping Guo4Jieyu Liu5Siyun Li6Jihua Huang7Jiawei Geng8Jiawei Geng9Jiawei Geng10Fan Zhang11Qiang Guo12Department of Infectious Disease and Hepatic Disease, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaInstitute of Basic and Clinical Medicine, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaDepartment of Gastroenterology, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Infectious Disease and Hepatic Disease, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Gastroenterology, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaThe effects of Helicobacter pylori eradication on gastric mucosa-colonizing microbes in patients with functional dyspepsia (FD) remain unclear. Here, we explored microbial variation induced by H. pylori infection and eradication treatment in FD patients. Gastric microbial abundance and diversity were significantly reduced in the H. pylori-infected FD patients. Eradication treatment increased alpha and beta diversity of gastric mucosa-colonizing microbes, and promoted the expansion of several probiotic microbes, such as Leuconostoc mesenteroides, which exhibited a matched antagonistic performance against H. pylori. Significant variation was observed in gastric mucosa-colonizing microbes between H. pylori-positive and H. pylori-negative FD patients. Eradication treatment induced microbial diversity recovery and may provide sufficient nutrition and space for probiotic microbes, such as Leuconostoc mesenteroides.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1288920/fullfunctional dyspepsiagastric microbemicrobial diversityHelicobacter pylorieradication therapy |
| spellingShingle | Wenxue Wang Wenxue Wang Zhongjian Liu Yu Zhang Zhiping Guo Jieyu Liu Siyun Li Jihua Huang Jiawei Geng Jiawei Geng Jiawei Geng Fan Zhang Qiang Guo Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy Frontiers in Microbiology functional dyspepsia gastric microbe microbial diversity Helicobacter pylori eradication therapy |
| title | Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy |
| title_full | Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy |
| title_fullStr | Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy |
| title_full_unstemmed | Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy |
| title_short | Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy |
| title_sort | diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after helicobacter pylori eradication therapy |
| topic | functional dyspepsia gastric microbe microbial diversity Helicobacter pylori eradication therapy |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1288920/full |
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