Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy
Background and Objectives: Zinc deficiency often occurs in patients with diabetes. Therefore, the relationship between zinc status and progression of nephropathy in diabetes has been explored. Materials and Methods: Total 300 diabetic patients and 100 non-diabetic healthy subjects (age matched)...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5082/10090_CE(JG)_F(Sh)_PF1(AJAK)_PFA(AK).pdf |
| _version_ | 1819124776151547904 |
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| author | Dhia J. Al-Timimi Dhia M. Sulieman Kajeen R. Hussen |
| author_facet | Dhia J. Al-Timimi Dhia M. Sulieman Kajeen R. Hussen |
| author_sort | Dhia J. Al-Timimi |
| collection | DOAJ |
| description | Background and Objectives: Zinc deficiency often occurs in
patients with diabetes. Therefore, the relationship between zinc
status and progression of nephropathy in diabetes has been
explored.
Materials and Methods: Total 300 diabetic patients and
100 non-diabetic healthy subjects (age matched) were
selected followed by informed consent and divided into
five groups as I: non-diabetic normotensive control; II:
diabetic normotensive; III: diabetic hypertensive; IV: diabetic
normotensive with microalbuminuria; V: diabetic hypertensive
with microalbuminuria. The blood samples of all subjects were
collected and analyzed for serum zinc, serum creatinine, and
estimated-glomerular filtration rate (e-GFR). Urine zinc, creatinine
and microalbuminuria concentrations were determined.
Results: The serum zinc levels were low (p<0.01) in diabetic
patients as compared to non-diabetic control subjects. The
lower levels (p<0.001) of serum zinc were observed in Group
IV and V as compared to group I-III. Significantly low levels of
e-GFR (p<0.05) and high levels of microalbuminuria (p<0.001)
were observed in diabetic patients with low serum zinc level as
compared to normal serum zinc level. Serum zinc level in diabetic
patients was inversely correlated with serum creatinine(r=-0.331,
p<0.001), microalbuminuria (r=-0.587, p<0.001) and positively
with e-GFR (r=0.194, p<0.01).
Conclusion: It is evident from this study that advancing diabetic
nephropathy represented by decreasing GFR and increasing
microalbuminuria is associated with lower serum zinc levels. It
thus indicates the need for determining serum zinc levels and
the effectiveness of zinc supplementation in diabetic patients,
particularly during the assessment of kidney damage. |
| first_indexed | 2024-12-22T07:29:37Z |
| format | Article |
| id | doaj.art-e49b36622f7c4513b945198161d69b9c |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T07:29:37Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-e49b36622f7c4513b945198161d69b9c2022-12-21T18:34:05ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811CC04CC0610.7860/JCDR/2014/10090.5082Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic NephropathyDhia J. Al-Timimi0Dhia M. Sulieman1Kajeen R. Hussen2Head, Department of Clinical Biochemistry, Duhok Diabetes Center, University of Duhok, Duhok, Iraq.Dean of College of Health Technology, Duhok Diabetes Center, University of Duhok, Duhok, Iraq. Assistant Lecture, Department of Clinical Biochemistry, Duhok Diabetes Center, University of Duhok, Duhok, Iraq.Background and Objectives: Zinc deficiency often occurs in patients with diabetes. Therefore, the relationship between zinc status and progression of nephropathy in diabetes has been explored. Materials and Methods: Total 300 diabetic patients and 100 non-diabetic healthy subjects (age matched) were selected followed by informed consent and divided into five groups as I: non-diabetic normotensive control; II: diabetic normotensive; III: diabetic hypertensive; IV: diabetic normotensive with microalbuminuria; V: diabetic hypertensive with microalbuminuria. The blood samples of all subjects were collected and analyzed for serum zinc, serum creatinine, and estimated-glomerular filtration rate (e-GFR). Urine zinc, creatinine and microalbuminuria concentrations were determined. Results: The serum zinc levels were low (p<0.01) in diabetic patients as compared to non-diabetic control subjects. The lower levels (p<0.001) of serum zinc were observed in Group IV and V as compared to group I-III. Significantly low levels of e-GFR (p<0.05) and high levels of microalbuminuria (p<0.001) were observed in diabetic patients with low serum zinc level as compared to normal serum zinc level. Serum zinc level in diabetic patients was inversely correlated with serum creatinine(r=-0.331, p<0.001), microalbuminuria (r=-0.587, p<0.001) and positively with e-GFR (r=0.194, p<0.01). Conclusion: It is evident from this study that advancing diabetic nephropathy represented by decreasing GFR and increasing microalbuminuria is associated with lower serum zinc levels. It thus indicates the need for determining serum zinc levels and the effectiveness of zinc supplementation in diabetic patients, particularly during the assessment of kidney damage.https://jcdr.net/articles/PDF/5082/10090_CE(JG)_F(Sh)_PF1(AJAK)_PFA(AK).pdfdiabetesnephropathyzinc |
| spellingShingle | Dhia J. Al-Timimi Dhia M. Sulieman Kajeen R. Hussen Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy Journal of Clinical and Diagnostic Research diabetes nephropathy zinc |
| title | Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy |
| title_full | Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy |
| title_fullStr | Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy |
| title_full_unstemmed | Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy |
| title_short | Zinc Status in Type 2 Diabetic Patients: Relation to the Progression of Diabetic Nephropathy |
| title_sort | zinc status in type 2 diabetic patients relation to the progression of diabetic nephropathy |
| topic | diabetes nephropathy zinc |
| url | https://jcdr.net/articles/PDF/5082/10090_CE(JG)_F(Sh)_PF1(AJAK)_PFA(AK).pdf |
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