Diet–microbial cross–talk underlying increased visceral perception
ABSTRACTVisceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can result from both central or peripheral factors, or their combination. As an important regulator of normal gut function, the gut microbiota has been implicated as a key peripheral factor in the pathophy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2166780 |
| _version_ | 1797236686467366912 |
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| author | Giada De Palma David E. Reed Premysl Bercik |
| author_facet | Giada De Palma David E. Reed Premysl Bercik |
| author_sort | Giada De Palma |
| collection | DOAJ |
| description | ABSTRACTVisceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can result from both central or peripheral factors, or their combination. As an important regulator of normal gut function, the gut microbiota has been implicated as a key peripheral factor in the pathophysiology of visceral hypersensitivity. Patients with chronic gastrointestinal disorders, such as irritable bowel syndrome, often present with abdominal pain secondary to adverse reactions to dietary components. As both long- and short-term diets are major determinants of gut microbiota configuration that can result in changes in microbial metabolic output, it is becoming increasingly recognized that diet–microbiota interactions play an important role in the genesis of visceral sensitivity. Changes in pain signaling may occur via diet-induced changes in secretion of mediators by both the microbiota and/or host cells. This review will examine the peripheral influence of diet–microbiota interactions underlying increased visceral sensitivity. |
| first_indexed | 2024-03-11T14:20:50Z |
| format | Article |
| id | doaj.art-e49c23f84da94cd7995bb09a6f90b4e3 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:48Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-e49c23f84da94cd7995bb09a6f90b4e32024-03-28T22:38:19ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2166780Diet–microbial cross–talk underlying increased visceral perceptionGiada De Palma0David E. Reed1Premysl Bercik2Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, CanadaGI Diseases Research Unit, Queens University, Kingston, Ontario, CanadaFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, CanadaABSTRACTVisceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can result from both central or peripheral factors, or their combination. As an important regulator of normal gut function, the gut microbiota has been implicated as a key peripheral factor in the pathophysiology of visceral hypersensitivity. Patients with chronic gastrointestinal disorders, such as irritable bowel syndrome, often present with abdominal pain secondary to adverse reactions to dietary components. As both long- and short-term diets are major determinants of gut microbiota configuration that can result in changes in microbial metabolic output, it is becoming increasingly recognized that diet–microbiota interactions play an important role in the genesis of visceral sensitivity. Changes in pain signaling may occur via diet-induced changes in secretion of mediators by both the microbiota and/or host cells. This review will examine the peripheral influence of diet–microbiota interactions underlying increased visceral sensitivity.https://www.tandfonline.com/doi/10.1080/19490976.2023.2166780dietmicrobiomeabdominal painvisceral hypersensitivityirritable bowel syndromeFODMAPs |
| spellingShingle | Giada De Palma David E. Reed Premysl Bercik Diet–microbial cross–talk underlying increased visceral perception Gut Microbes diet microbiome abdominal pain visceral hypersensitivity irritable bowel syndrome FODMAPs |
| title | Diet–microbial cross–talk underlying increased visceral perception |
| title_full | Diet–microbial cross–talk underlying increased visceral perception |
| title_fullStr | Diet–microbial cross–talk underlying increased visceral perception |
| title_full_unstemmed | Diet–microbial cross–talk underlying increased visceral perception |
| title_short | Diet–microbial cross–talk underlying increased visceral perception |
| title_sort | diet microbial cross talk underlying increased visceral perception |
| topic | diet microbiome abdominal pain visceral hypersensitivity irritable bowel syndrome FODMAPs |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2166780 |
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