Sensitivity to change and minimal clinically important difference of the angioedema control test
Abstract Background The Angioedema Control Test (AECT) is a patient‐reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivity to change and minimal clinically important difference (MCID) have hitherto not been establ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.12295 |
| _version_ | 1797674801098129408 |
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| author | Lauré M. Fijen Carolina Vera Thomas Buttgereit Hanna Bonnekoh Marcus Maurer Markus Magerl Karsten Weller |
| author_facet | Lauré M. Fijen Carolina Vera Thomas Buttgereit Hanna Bonnekoh Marcus Maurer Markus Magerl Karsten Weller |
| author_sort | Lauré M. Fijen |
| collection | DOAJ |
| description | Abstract Background The Angioedema Control Test (AECT) is a patient‐reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivity to change and minimal clinically important difference (MCID) have hitherto not been established. Methods Patients with recurrent angioedema due to chronic spontaneous urticaria, hereditary angioedema, or acquired C1‐inhibitor deficiency were repeatedly asked to complete the AECT along with the Angioedema Quality of Life Questionnaire (AE‐QoL), Dermatology Life Quality Index (DLQI), and anchors for disease control and whether treatment was sufficient during routine care visits. The sensitivity to the change of the AECT was determined by correlating changes in its scores over time with changes in the applied anchors. The MCID was determined using anchor‐based and distributional criterion‐based approaches. Results Eighty‐six cases were used for this analysis. Changes in AECT scores correlated well with AE‐QoL changes (but less with changes in the DLQI) as well as other applied anchors, demonstrating its sensitivity to change. The MCID was found to be three points for improvement of angioedema control. The available number of cases with meaningful deterioration in our dataset was too low to reach a definite conclusion on the MCID for deterioration of angioedema control. Conclusion The AECT is a valuable tool to assess changes in disease control in patients with recurrent angioedema over time. The lowest AECT score change that reflects a meaningful improvement of disease control to patients (MCID) is three points. |
| first_indexed | 2024-03-11T22:04:17Z |
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| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-03-11T22:04:17Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-e4a1c1f171b74b6b9c1e23c3723499c52023-09-25T09:20:53ZengWileyClinical and Translational Allergy2045-70222023-09-01139n/an/a10.1002/clt2.12295Sensitivity to change and minimal clinically important difference of the angioedema control testLauré M. Fijen0Carolina Vera1Thomas Buttgereit2Hanna Bonnekoh3Marcus Maurer4Markus Magerl5Karsten Weller6Department of Vascular Medicine Amsterdam Cardiovascular Sciences Amsterdam UMC University of Amsterdam Amsterdam The NetherlandsInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology Charité ‐ Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyAbstract Background The Angioedema Control Test (AECT) is a patient‐reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivity to change and minimal clinically important difference (MCID) have hitherto not been established. Methods Patients with recurrent angioedema due to chronic spontaneous urticaria, hereditary angioedema, or acquired C1‐inhibitor deficiency were repeatedly asked to complete the AECT along with the Angioedema Quality of Life Questionnaire (AE‐QoL), Dermatology Life Quality Index (DLQI), and anchors for disease control and whether treatment was sufficient during routine care visits. The sensitivity to the change of the AECT was determined by correlating changes in its scores over time with changes in the applied anchors. The MCID was determined using anchor‐based and distributional criterion‐based approaches. Results Eighty‐six cases were used for this analysis. Changes in AECT scores correlated well with AE‐QoL changes (but less with changes in the DLQI) as well as other applied anchors, demonstrating its sensitivity to change. The MCID was found to be three points for improvement of angioedema control. The available number of cases with meaningful deterioration in our dataset was too low to reach a definite conclusion on the MCID for deterioration of angioedema control. Conclusion The AECT is a valuable tool to assess changes in disease control in patients with recurrent angioedema over time. The lowest AECT score change that reflects a meaningful improvement of disease control to patients (MCID) is three points.https://doi.org/10.1002/clt2.12295angioedemadisease controlminimal clinically important difference (MCID)7patient‐reported outcome measures (PROMs)sensitivity to change |
| spellingShingle | Lauré M. Fijen Carolina Vera Thomas Buttgereit Hanna Bonnekoh Marcus Maurer Markus Magerl Karsten Weller Sensitivity to change and minimal clinically important difference of the angioedema control test Clinical and Translational Allergy angioedema disease control minimal clinically important difference (MCID)7 patient‐reported outcome measures (PROMs) sensitivity to change |
| title | Sensitivity to change and minimal clinically important difference of the angioedema control test |
| title_full | Sensitivity to change and minimal clinically important difference of the angioedema control test |
| title_fullStr | Sensitivity to change and minimal clinically important difference of the angioedema control test |
| title_full_unstemmed | Sensitivity to change and minimal clinically important difference of the angioedema control test |
| title_short | Sensitivity to change and minimal clinically important difference of the angioedema control test |
| title_sort | sensitivity to change and minimal clinically important difference of the angioedema control test |
| topic | angioedema disease control minimal clinically important difference (MCID)7 patient‐reported outcome measures (PROMs) sensitivity to change |
| url | https://doi.org/10.1002/clt2.12295 |
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