Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole formation. Abemaciclib-SPyADI-treatment suppresses D...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-06-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05006-1 |
| _version_ | 1811243866536280064 |
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| author | Christin Riess Katharina del Moral Adina Fiebig Philipp Kaps Charlotte Linke Burkhard Hinz Anne Rupprecht Marcus Frank Tomas Fiedler Dirk Koczan Sascha Troschke-Meurer Holger N. Lode Nadja Engel Thomas Freitag Carl Friedrich Classen Claudia Maletzki |
| author_facet | Christin Riess Katharina del Moral Adina Fiebig Philipp Kaps Charlotte Linke Burkhard Hinz Anne Rupprecht Marcus Frank Tomas Fiedler Dirk Koczan Sascha Troschke-Meurer Holger N. Lode Nadja Engel Thomas Freitag Carl Friedrich Classen Claudia Maletzki |
| author_sort | Christin Riess |
| collection | DOAJ |
| description | The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole formation. Abemaciclib-SPyADI-treatment suppresses DNA repair, dinaciclib-SpyADI-treatment enhances γ-H2AX accumulation and activates the stress sensor GADD45 and β-catenin antagonist AXIN2. Both CDKi/SpyADI combinations significantly boost cell death. |
| first_indexed | 2024-04-12T14:14:45Z |
| format | Article |
| id | doaj.art-e4a237d57e9d4704bd9c0f69a431ba27 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-12T14:14:45Z |
| publishDate | 2022-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-e4a237d57e9d4704bd9c0f69a431ba272022-12-22T03:29:46ZengNature Publishing GroupCell Death and Disease2041-48892022-06-0113611410.1038/s41419-022-05006-1Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cellsChristin Riess0Katharina del Moral1Adina Fiebig2Philipp Kaps3Charlotte Linke4Burkhard Hinz5Anne Rupprecht6Marcus Frank7Tomas Fiedler8Dirk Koczan9Sascha Troschke-Meurer10Holger N. Lode11Nadja Engel12Thomas Freitag13Carl Friedrich Classen14Claudia Maletzki15University Children’s Hospital, Rostock University Medical CenterUniversity Children’s Hospital, Rostock University Medical CenterInstitute for Medical Microbiology, Virology, and Hygiene, Rostock University Medical CenterUniversity Children’s Hospital, Rostock University Medical CenterUniversity Children’s Hospital, Rostock University Medical CenterInstitute for Pharmacology and Toxicology, Rostock University Medical CenterInstitute for Pharmacology and Toxicology, Rostock University Medical CenterMedical Biology and Electron Microscopy Center, Rostock University Medical CenterInstitute for Medical Microbiology, Virology, and Hygiene, Rostock University Medical CenterInstitute for Immunology, University of RostockDepartment of Pediatric Oncology and Hematology, University Medicine Greifswald, Ferdinand-Sauerbruch-StrasseDepartment of Pediatric Oncology and Hematology, University Medicine Greifswald, Ferdinand-Sauerbruch-StrasseDepartment of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical CenterDepartment of Medicine, Clinic III - Hematology, Oncology, Palliative Medicine, Rostock University Medical CenterUniversity Children’s Hospital, Rostock University Medical CenterDepartment of Medicine, Clinic III - Hematology, Oncology, Palliative Medicine, Rostock University Medical CenterThe complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole formation. Abemaciclib-SPyADI-treatment suppresses DNA repair, dinaciclib-SpyADI-treatment enhances γ-H2AX accumulation and activates the stress sensor GADD45 and β-catenin antagonist AXIN2. Both CDKi/SpyADI combinations significantly boost cell death.https://doi.org/10.1038/s41419-022-05006-1 |
| spellingShingle | Christin Riess Katharina del Moral Adina Fiebig Philipp Kaps Charlotte Linke Burkhard Hinz Anne Rupprecht Marcus Frank Tomas Fiedler Dirk Koczan Sascha Troschke-Meurer Holger N. Lode Nadja Engel Thomas Freitag Carl Friedrich Classen Claudia Maletzki Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells Cell Death and Disease |
| title | Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells |
| title_full | Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells |
| title_fullStr | Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells |
| title_full_unstemmed | Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells |
| title_short | Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells |
| title_sort | implementation of a combined cdk inhibition and arginine deprivation approach to target arginine auxotrophic glioblastoma multiforme cells |
| url | https://doi.org/10.1038/s41419-022-05006-1 |
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