Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/2957 |
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| author | Dimitri Papukashvili Nino Rcheulishvili Cong Liu Fengfei Xie Deependra Tyagi Yunjiao He Peng George Wang |
| author_facet | Dimitri Papukashvili Nino Rcheulishvili Cong Liu Fengfei Xie Deependra Tyagi Yunjiao He Peng George Wang |
| author_sort | Dimitri Papukashvili |
| collection | DOAJ |
| description | Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy. |
| first_indexed | 2024-03-10T05:37:51Z |
| format | Article |
| id | doaj.art-e4a27aff5d79422abec24a1cddf5ced9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:51Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e4a27aff5d79422abec24a1cddf5ced92023-11-22T22:49:14ZengMDPI AGCells2073-44092021-10-011011295710.3390/cells10112957Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration TherapyDimitri Papukashvili0Nino Rcheulishvili1Cong Liu2Fengfei Xie3Deependra Tyagi4Yunjiao He5Peng George Wang6School of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen 518000, ChinaAndrogenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.https://www.mdpi.com/2073-4409/10/11/2957miRNAAGADKK1Wnt/β-cateninhair |
| spellingShingle | Dimitri Papukashvili Nino Rcheulishvili Cong Liu Fengfei Xie Deependra Tyagi Yunjiao He Peng George Wang Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells miRNA AGA DKK1 Wnt/β-catenin hair |
| title | Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy |
| title_full | Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy |
| title_fullStr | Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy |
| title_full_unstemmed | Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy |
| title_short | Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy |
| title_sort | perspectives on mirnas targeting dkk1 for developing hair regeneration therapy |
| topic | miRNA AGA DKK1 Wnt/β-catenin hair |
| url | https://www.mdpi.com/2073-4409/10/11/2957 |
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