Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226
Abstract Background Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-11-01
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| Series: | Botanical Studies |
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| Online Access: | https://doi.org/10.1186/s40529-023-00406-8 |
| _version_ | 1797415729252794368 |
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| author | Chia-Hao Chang George Hsiao Shih-Wei Wang Juei-Yu Yen Shu-Jung Huang Wei-Chiung Chi Tzong-Huei Lee |
| author_facet | Chia-Hao Chang George Hsiao Shih-Wei Wang Juei-Yu Yen Shu-Jung Huang Wei-Chiung Chi Tzong-Huei Lee |
| author_sort | Chia-Hao Chang |
| collection | DOAJ |
| description | Abstract Background Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1–14. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4–14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Conclusions Three previously unreported compounds 1–3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively. |
| first_indexed | 2024-03-09T05:52:42Z |
| format | Article |
| id | doaj.art-e4a3ad80208e490599be9a52e4a4f153 |
| institution | Directory Open Access Journal |
| issn | 1999-3110 |
| language | English |
| last_indexed | 2024-03-09T05:52:42Z |
| publishDate | 2023-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Botanical Studies |
| spelling | doaj.art-e4a3ad80208e490599be9a52e4a4f1532023-12-03T12:16:08ZengSpringerOpenBotanical Studies1999-31102023-11-016411910.1186/s40529-023-00406-8Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226Chia-Hao Chang0George Hsiao1Shih-Wei Wang2Juei-Yu Yen3Shu-Jung Huang4Wei-Chiung Chi5Tzong-Huei Lee6Institute of Fisheries Science, College of Life Science, National Taiwan UniversityDepartment of Pharmacology, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Medicine, MacKay Medical CollegeInstitute of Biomedical Sciences, Mackay Medical CollegeInstitute of Fisheries Science, College of Life Science, National Taiwan UniversityDepartment of Food Science, National Quemoy UniversityInstitute of Fisheries Science, College of Life Science, National Taiwan UniversityAbstract Background Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1–14. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4–14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Conclusions Three previously unreported compounds 1–3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively.https://doi.org/10.1186/s40529-023-00406-8Chaetomium globosumAureonitolMollipilinPolyketideAnti-inflammationAnti-angiogenesis |
| spellingShingle | Chia-Hao Chang George Hsiao Shih-Wei Wang Juei-Yu Yen Shu-Jung Huang Wei-Chiung Chi Tzong-Huei Lee Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 Botanical Studies Chaetomium globosum Aureonitol Mollipilin Polyketide Anti-inflammation Anti-angiogenesis |
| title | Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 |
| title_full | Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 |
| title_fullStr | Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 |
| title_full_unstemmed | Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 |
| title_short | Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226 |
| title_sort | chemical constituents from the medicinal herb derived fungus chaetomium globosum km1226 |
| topic | Chaetomium globosum Aureonitol Mollipilin Polyketide Anti-inflammation Anti-angiogenesis |
| url | https://doi.org/10.1186/s40529-023-00406-8 |
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