Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Abstract Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM progression. Cells within this region adapt to hypo...

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Bibliographic Details
Main Authors: Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván, Judit Herreros
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06492-1

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