Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease
Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several steps of vesicle trafficking, Rabs have been implicated in the pathogenesis of several disorders, including cancer, diabetes, and multiple neuro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1141 |
| _version_ | 1827670146919956480 |
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| author | Kate L. Jordan David J. Koss Tiago F. Outeiro Flaviano Giorgini |
| author_facet | Kate L. Jordan David J. Koss Tiago F. Outeiro Flaviano Giorgini |
| author_sort | Kate L. Jordan |
| collection | DOAJ |
| description | Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several steps of vesicle trafficking, Rabs have been implicated in the pathogenesis of several disorders, including cancer, diabetes, and multiple neurodegenerative diseases. As treatments for neurodegenerative conditions are currently rather limited, the identification and validation of novel therapeutic targets, such as Rabs, is of great importance. This review summarises proof-of-concept studies, demonstrating that modulation of Rab GTPases in the context of Alzheimer’s disease (AD) can ameliorate disease-related phenotypes, and provides an overview of the current state of the art for the pharmacological targeting of Rabs. Finally, we also discuss the barriers and challenges of therapeutically targeting these small proteins in humans, especially in the context of AD. |
| first_indexed | 2024-03-10T03:16:58Z |
| format | Article |
| id | doaj.art-e4a47ef9a7cc4e0c8fe17fa93e15b42e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:16:58Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e4a47ef9a7cc4e0c8fe17fa93e15b42e2023-11-23T10:11:38ZengMDPI AGBiomedicines2227-90592022-05-01105114110.3390/biomedicines10051141Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s DiseaseKate L. Jordan0David J. Koss1Tiago F. Outeiro2Flaviano Giorgini3Department of Genetics and Genome Biology, University of Leicester, University Road, Leicester LE1 7RH, UKFaculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UKFaculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UKDepartment of Genetics and Genome Biology, University of Leicester, University Road, Leicester LE1 7RH, UKRab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several steps of vesicle trafficking, Rabs have been implicated in the pathogenesis of several disorders, including cancer, diabetes, and multiple neurodegenerative diseases. As treatments for neurodegenerative conditions are currently rather limited, the identification and validation of novel therapeutic targets, such as Rabs, is of great importance. This review summarises proof-of-concept studies, demonstrating that modulation of Rab GTPases in the context of Alzheimer’s disease (AD) can ameliorate disease-related phenotypes, and provides an overview of the current state of the art for the pharmacological targeting of Rabs. Finally, we also discuss the barriers and challenges of therapeutically targeting these small proteins in humans, especially in the context of AD.https://www.mdpi.com/2227-9059/10/5/1141Rab GTPasesAlzheimer’sneurodegeneration |
| spellingShingle | Kate L. Jordan David J. Koss Tiago F. Outeiro Flaviano Giorgini Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease Biomedicines Rab GTPases Alzheimer’s neurodegeneration |
| title | Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease |
| title_full | Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease |
| title_fullStr | Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease |
| title_full_unstemmed | Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease |
| title_short | Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease |
| title_sort | therapeutic targeting of rab gtpases relevance for alzheimer s disease |
| topic | Rab GTPases Alzheimer’s neurodegeneration |
| url | https://www.mdpi.com/2227-9059/10/5/1141 |
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