Stress & the gut-brain axis: Regulation by the microbiome
The importance of the gutâbrain axis in regulating stress-related responses has long been appreciated. More recently, the microbiota has emerged as a key player in the control of this axis, especially during conditions of stress provoked by real or perceived homeostatic challenge. Diet is one of the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | Neurobiology of Stress |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289516300509 |
| _version_ | 1828434981224972288 |
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| author | Jane A. Foster Linda Rinaman John F. Cryan |
| author_facet | Jane A. Foster Linda Rinaman John F. Cryan |
| author_sort | Jane A. Foster |
| collection | DOAJ |
| description | The importance of the gutâbrain axis in regulating stress-related responses has long been appreciated. More recently, the microbiota has emerged as a key player in the control of this axis, especially during conditions of stress provoked by real or perceived homeostatic challenge. Diet is one of the most important modifying factors of the microbiota-gut-brain axis. The routes of communication between the microbiota and brain are slowly being unravelled, and include the vagus nerve, gut hormone signaling, the immune system, tryptophan metabolism, and microbial metabolites such as short chain fatty acids. The importance of the early life gut microbiota in shaping later health outcomes also is emerging. Results from preclinical studies indicate that alterations of the early microbial composition by way of antibiotic exposure, lack of breastfeeding, birth by Caesarean section, infection, stress exposure, and other environmental influences - coupled with the influence of host genetics - can result in long-term modulation of stress-related physiology and behaviour. The gut microbiota has been implicated in a variety of stress-related conditions including anxiety, depression and irritable bowel syndrome, although this is largely based on animal studies or correlative analysis in patient populations. Additional research in humans is sorely needed to reveal the relative impact and causal contribution of the microbiome to stress-related disorders. In this regard, the concept of psychobiotics is being developed and refined to encompass methods of targeting the microbiota in order to positively impact mental health outcomes. At the 2016 Neurobiology of Stress Workshop in Newport Beach, CA, a group of experts presented the symposium âThe Microbiome: Development, Stress, and Diseaseâ. This report summarizes and builds upon some of the key concepts in that symposium within the context of how microbiota might influence the neurobiology of stress. |
| first_indexed | 2024-12-10T18:59:49Z |
| format | Article |
| id | doaj.art-e4a6afaeb091489a9a8386a9b1681916 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-12-10T18:59:49Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-e4a6afaeb091489a9a8386a9b16819162022-12-22T01:37:03ZengElsevierNeurobiology of Stress2352-28952017-12-017124136Stress & the gut-brain axis: Regulation by the microbiomeJane A. Foster0Linda Rinaman1John F. Cryan2Department of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, Ontario, CanadaDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Corresponding author. Current address: Department of Psychology, Florida State University, Tallahassee, FL, United StatesAPC Microbiome Institute, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, IrelandThe importance of the gutâbrain axis in regulating stress-related responses has long been appreciated. More recently, the microbiota has emerged as a key player in the control of this axis, especially during conditions of stress provoked by real or perceived homeostatic challenge. Diet is one of the most important modifying factors of the microbiota-gut-brain axis. The routes of communication between the microbiota and brain are slowly being unravelled, and include the vagus nerve, gut hormone signaling, the immune system, tryptophan metabolism, and microbial metabolites such as short chain fatty acids. The importance of the early life gut microbiota in shaping later health outcomes also is emerging. Results from preclinical studies indicate that alterations of the early microbial composition by way of antibiotic exposure, lack of breastfeeding, birth by Caesarean section, infection, stress exposure, and other environmental influences - coupled with the influence of host genetics - can result in long-term modulation of stress-related physiology and behaviour. The gut microbiota has been implicated in a variety of stress-related conditions including anxiety, depression and irritable bowel syndrome, although this is largely based on animal studies or correlative analysis in patient populations. Additional research in humans is sorely needed to reveal the relative impact and causal contribution of the microbiome to stress-related disorders. In this regard, the concept of psychobiotics is being developed and refined to encompass methods of targeting the microbiota in order to positively impact mental health outcomes. At the 2016 Neurobiology of Stress Workshop in Newport Beach, CA, a group of experts presented the symposium âThe Microbiome: Development, Stress, and Diseaseâ. This report summarizes and builds upon some of the key concepts in that symposium within the context of how microbiota might influence the neurobiology of stress.http://www.sciencedirect.com/science/article/pii/S2352289516300509 |
| spellingShingle | Jane A. Foster Linda Rinaman John F. Cryan Stress & the gut-brain axis: Regulation by the microbiome Neurobiology of Stress |
| title | Stress & the gut-brain axis: Regulation by the microbiome |
| title_full | Stress & the gut-brain axis: Regulation by the microbiome |
| title_fullStr | Stress & the gut-brain axis: Regulation by the microbiome |
| title_full_unstemmed | Stress & the gut-brain axis: Regulation by the microbiome |
| title_short | Stress & the gut-brain axis: Regulation by the microbiome |
| title_sort | stress the gut brain axis regulation by the microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2352289516300509 |
| work_keys_str_mv | AT janeafoster stressthegutbrainaxisregulationbythemicrobiome AT lindarinaman stressthegutbrainaxisregulationbythemicrobiome AT johnfcryan stressthegutbrainaxisregulationbythemicrobiome |