Anti-NMDA-receptor antibody encephalitis in infants
Purpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms. The clinical course is one of progressive clinical deterioration that can be halted and often reversed by early diagno...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Epilepsy and Behavior Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213323215000341 |
| _version_ | 1818498528059588608 |
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| author | Amr A. Matoq Adam S. Rappoport Yiting Yang Jessica O'Babatunde Rubina Bakerywala Raj D. Sheth |
| author_facet | Amr A. Matoq Adam S. Rappoport Yiting Yang Jessica O'Babatunde Rubina Bakerywala Raj D. Sheth |
| author_sort | Amr A. Matoq |
| collection | DOAJ |
| description | Purpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms. The clinical course is one of progressive clinical deterioration that can be halted and often reversed by early diagnosis and treatment. Patterns of presentation and etiology of anti-NMDA-receptor antibody encephalitis are dependent on age and can be challenging to recognize in very young children.
Reports: Sequential clinical case observations of anti-NMDA-receptor antibody encephalitis presenting in very young children were examined over a year at a single tertiary pediatric institution. Cerebrospinal fluid confirmed anti-NMDA-receptor antibodies in two cases (a 21-month-old boy and a 29-month-old girl) that demonstrated either bizarre behavioral patterns or status epilepticus both associated with progressive deterioration. Once recognized, the clinical course was arrested and reversed by aggressive treatment with plasma exchange, immunoglobulin, and high dose IV steroids.
Conclusion: Infants with anti-NMDA-receptor antibody encephalitis can present with frank seizures or seizure mimics. Regardless, prompt recognition and aggressive treatment of anti-NMDA-receptor antibody encephalitis, while challenging, can quickly arrest deterioration and hasten recovery, thereby, limiting neurological morbidity. |
| first_indexed | 2024-12-10T20:16:52Z |
| format | Article |
| id | doaj.art-e4aa4ec8ece64d42804c0f945a4ac1c9 |
| institution | Directory Open Access Journal |
| issn | 2213-3232 |
| language | English |
| last_indexed | 2024-12-10T20:16:52Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy and Behavior Case Reports |
| spelling | doaj.art-e4aa4ec8ece64d42804c0f945a4ac1c92022-12-22T01:35:11ZengElsevierEpilepsy and Behavior Case Reports2213-32322015-01-014C9910110.1016/j.ebcr.2015.07.005Anti-NMDA-receptor antibody encephalitis in infantsAmr A. Matoq0Adam S. Rappoport1Yiting Yang2Jessica O'Babatunde3Rubina Bakerywala4Raj D. Sheth5University of Florida & Wolfson Children Hospital, Jacksonville, FL, USANemours Children Health System, Jacksonville, FL, USANemours Children Health System, Jacksonville, FL, USAUniversity of Florida & Wolfson Children Hospital, Jacksonville, FL, USANemours Children Health System, Jacksonville, FL, USAUniversity of Florida & Wolfson Children Hospital, Jacksonville, FL, USAPurpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms. The clinical course is one of progressive clinical deterioration that can be halted and often reversed by early diagnosis and treatment. Patterns of presentation and etiology of anti-NMDA-receptor antibody encephalitis are dependent on age and can be challenging to recognize in very young children. Reports: Sequential clinical case observations of anti-NMDA-receptor antibody encephalitis presenting in very young children were examined over a year at a single tertiary pediatric institution. Cerebrospinal fluid confirmed anti-NMDA-receptor antibodies in two cases (a 21-month-old boy and a 29-month-old girl) that demonstrated either bizarre behavioral patterns or status epilepticus both associated with progressive deterioration. Once recognized, the clinical course was arrested and reversed by aggressive treatment with plasma exchange, immunoglobulin, and high dose IV steroids. Conclusion: Infants with anti-NMDA-receptor antibody encephalitis can present with frank seizures or seizure mimics. Regardless, prompt recognition and aggressive treatment of anti-NMDA-receptor antibody encephalitis, while challenging, can quickly arrest deterioration and hasten recovery, thereby, limiting neurological morbidity.http://www.sciencedirect.com/science/article/pii/S2213323215000341Anti-NMDAREncephalitisChildParaneoplastic syndromePsychosisBehavioral outburst |
| spellingShingle | Amr A. Matoq Adam S. Rappoport Yiting Yang Jessica O'Babatunde Rubina Bakerywala Raj D. Sheth Anti-NMDA-receptor antibody encephalitis in infants Epilepsy and Behavior Case Reports Anti-NMDAR Encephalitis Child Paraneoplastic syndrome Psychosis Behavioral outburst |
| title | Anti-NMDA-receptor antibody encephalitis in infants |
| title_full | Anti-NMDA-receptor antibody encephalitis in infants |
| title_fullStr | Anti-NMDA-receptor antibody encephalitis in infants |
| title_full_unstemmed | Anti-NMDA-receptor antibody encephalitis in infants |
| title_short | Anti-NMDA-receptor antibody encephalitis in infants |
| title_sort | anti nmda receptor antibody encephalitis in infants |
| topic | Anti-NMDAR Encephalitis Child Paraneoplastic syndrome Psychosis Behavioral outburst |
| url | http://www.sciencedirect.com/science/article/pii/S2213323215000341 |
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