Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC)
Background: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors. This study aimed to evaluate the relevance of vascular endothelial growth factor (VEGF) and cytokeratin 19 (CK19) genes as biomarkers for diagnosis of OSCC. Methods: In this study, 30 patients and 30 heal...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2019-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/11826 |
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| author | Parisa Nabavi Abdolreza Mohamadnia Maryam Naseroleslami Naghmeh Bahrami |
| author_facet | Parisa Nabavi Abdolreza Mohamadnia Maryam Naseroleslami Naghmeh Bahrami |
| author_sort | Parisa Nabavi |
| collection | DOAJ |
| description | Background: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors. This study aimed to evaluate the relevance of vascular endothelial growth factor (VEGF) and cytokeratin 19 (CK19) genes as biomarkers for diagnosis of OSCC.
Methods: In this study, 30 patients and 30 healthy individuals were selected. CK19 and VEGF were measured in peripheral blood using real-time polymerase chain reaction (PCR) technique. T-test was performed to analyze the data.
Findings: In patients with OSCC, CK19 and VEGF markers were positive in 17 and 23 patients out of 30.
Conclusion: The expression of VEGF and CK19 is more among the patients with OSCC, compared to healthy people. In summary, the result of this study can be considered as a diagnostic screening test in the early stages of the disease. |
| first_indexed | 2024-03-12T08:27:18Z |
| format | Article |
| id | doaj.art-e4ac1d5bc8db46599f3c9c9d855c194c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:27:18Z |
| publishDate | 2019-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-e4ac1d5bc8db46599f3c9c9d855c194c2023-09-02T18:01:25ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-08-013752648048410.22122/jims.v37i526.118263414Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC)Parisa Nabavi0Abdolreza Mohamadnia1Maryam Naseroleslami2Naghmeh Bahrami3Department of Cellular and Molecular Biology, School of Advanced Science and Technology, Tehran Medical Branch, Islamic Azad University, Tehran, IranAssistant Professor, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) AND Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranAssistant Professor, Department of Cellular and Molecular Biology, School of Advanced Science and Technology, Tehran Medical Branch, Islamic Azad University, Tehran, IranAssistant Professor, Craniomaxillofacial Research Center AND Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranBackground: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors. This study aimed to evaluate the relevance of vascular endothelial growth factor (VEGF) and cytokeratin 19 (CK19) genes as biomarkers for diagnosis of OSCC. Methods: In this study, 30 patients and 30 healthy individuals were selected. CK19 and VEGF were measured in peripheral blood using real-time polymerase chain reaction (PCR) technique. T-test was performed to analyze the data. Findings: In patients with OSCC, CK19 and VEGF markers were positive in 17 and 23 patients out of 30. Conclusion: The expression of VEGF and CK19 is more among the patients with OSCC, compared to healthy people. In summary, the result of this study can be considered as a diagnostic screening test in the early stages of the disease.http://jims.mui.ac.ir/index.php/jims/article/view/11826Head and neck squamous cell carcinomaCytokeratin 19Vascular endothelial growth factor |
| spellingShingle | Parisa Nabavi Abdolreza Mohamadnia Maryam Naseroleslami Naghmeh Bahrami Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) مجله دانشکده پزشکی اصفهان Head and neck squamous cell carcinoma Cytokeratin 19 Vascular endothelial growth factor |
| title | Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) |
| title_full | Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) |
| title_fullStr | Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) |
| title_full_unstemmed | Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) |
| title_short | Expression of Cytokeratin 19 (CK19) and Vascular Endothelial Growth Factor (VEGF) Genes in Peripheral Blood of Patients with Oral Squamous Cell Carcinoma (OSCC) |
| title_sort | expression of cytokeratin 19 ck19 and vascular endothelial growth factor vegf genes in peripheral blood of patients with oral squamous cell carcinoma oscc |
| topic | Head and neck squamous cell carcinoma Cytokeratin 19 Vascular endothelial growth factor |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/11826 |
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