Preclinical Development of a Therapy for Chronic Traumatic Spinal Cord Injury in Rats Using Human Wharton’s Jelly Mesenchymal Stromal Cells: Proof of Concept and Regulatory Compliance

Preclinical Development of a Therapy for Chronic Traumatic Spinal Cord Injury in Rats Using Human Wharton’s Jelly Mesenchymal Stromal Cells: Proof of Concept and Regulatory Compliance

(1) Background: the use of Mesenchymal Stromal Cells (MSC) in emerging therapies for spinal cord injury (SCI) hold the potential to improve functional recovery. However, the development of cell-based medicines is challenging and preclinical studies addressing quality, safety and efficacy must be con...

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Bibliographic Details
Main Authors: Joaquim Vives, Joaquim Hernández, Clémentine Mirabel, Maria Puigdomenech-Poch, David Romeo-Guitart, Sara Marmolejo-Martínez-Artesero, Raquel Cabrera-Pérez, Jessica Jaramillo, Hatice Kumru, Joan García-López, Joan Vidal-Samsó, Xavier Navarro, Ruth Coll-Bonet
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
mesenchymal stromal cells
translational medicine
cell therapy
stem cells
cell-based therapy
spinal cord injury
Online Access:https://www.mdpi.com/2073-4409/11/14/2153

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