Improved prediction of MHC-peptide binding using protein language models

Improved prediction of MHC-peptide binding using protein language models

Major histocompatibility complex Class I (MHC-I) molecules bind to peptides derived from intracellular antigens and present them on the surface of cells, allowing the immune system (T cells) to detect them. Elucidating the process of this presentation is essential for regulation and potential manipu...

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Bibliographic Details
Main Authors: Nasser Hashemi, Boran Hao, Mikhail Ignatov, Ioannis Ch. Paschalidis, Pirooz Vakili, Sandor Vajda, Dima Kozakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Bioinformatics
Subjects:
MHC class I
deep learning
transformers
natural language processing
cellular immune system
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2023.1207380/full

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